5-aminolevulinic Acid Hydrochloride

5-aminolevulinic Acid Hydrochloride

Product name:5 Aminolevulinic Acid HCl
CAS:5451-09-2
Appearance:White powder
Assay: 95.0%-98.0%
Standard: GB, USP, EP
Certifications: ISO, HACCP, HALAL, KOSHER
Delivery: Shipped in Same day from stocks
Packing:
Carton:1-10kg
Drum: 20,25kg
Pallet:12drums/pallet,or 30cartons/pallet
Storage: Well-closed, dry place with constant 2-8℃
Description
Technical Parameters

Natural Field Bio-Technique : Your Trustworthy 5-Aminolevulinic Acid Hydrochloride Supplier!

 

 

Xi'an Natural Field Bio-Technique Co.,Ltd. owns the 2000 square meters cGMP factory and over 60 people.In this team, we have 5 professional technicist for quality control, 6 people for research and development, 22 factory workers and 16 sales staff,3 financial employees, 3 warehouse employees, 3 sourcing employees and so on. We have deep confidence to do the best service and the best quality for our global customers.

 

Our Advantages
 

Quality Guaranteed
Our company has passed ISO9001, ISO22000, Kosher, HACCP, HALAL, USA ORGANIC, EU ORGANIC, Food Production License, Business License, and other qualifications certificates.

 

Continuous Product Innovation
Our company has applied for several product patents. Over the years, our company positions at producing high-quality, fine technique, cutting-edge products. In addition, Natural Field's high-quality R&D team is constantly improving the technical level, improving equipment, and conducting independent research and development of new products to meet the needs of the market and customers.

 

Rich Products
Our company has advanced production equipment, such as standardized extract, cosmetic raw material, natural ingredients, supplement ingredients, superfoods powder, agricultural raw materials, hot selling, healthcare supplements.

 

24-Hour Service
Our company promises to provide 7×24 hours service after the contract is signed. We will respond within 1 hour after receiving the message, provide solutions to general faults within 8 hours, and solve complex problems within 24 hours.

 

 

What is 5-Aminolevulinic Acid Hydrochloride

 

 

5-Aminolevulinic Acid Hydrochloride (ALA Hydrochloride) is a derivative of 5-Aminolevulinic Acid (ALA), an endogenous non-protein amino acid that plays a crucial role in the heme biosynthesis pathway.

 

 
Properties
 
01/

Optical Properties
5-Aminolevulinic Acid Hydrochloride retains the optical properties of CY5 dye, with high fluorescence quantum yield and photostability. This enables it to maintain a stable fluorescence signal in complex biological environments, providing convenience for biological imaging and detection.

02/

Biological Activity
Because 5-Aminolevulinic Acid Hydrochloride contains alanine, a biologically active molecule, it may have certain biological activities. For example, it may be involved in biological processes such as protein synthesis, metabolism or signal transduction.

03/

Stability
The stability of 5-Aminolevulinic Acid Hydrochloride depends on its synthesis method and storage conditions. Under appropriate conditions, 5-Aminolevulinic Acid Hydrochloride can maintain long-term stability and play a lasting role in organisms.

04/

Specificity
Because 5-Aminolevulinic Acid Hydrochloride has specific fluorescence properties and biological activities, it may have certain specificity. For example, it may be able to specifically identify certain proteins, cells or tissues, providing useful tools for biomedical research and drug discovery.

 

Applications of 5-Aminolevulinic Acid Hydrochloride
 

Photodynamic Therapy (PDT)

5-Aminolevulinic Acid Hydrochloride is widely used in PDT for the treatment of certain types of skin cancers, including basal cell carcinoma and squamous cell carcinoma, as well as actinic keratosis. It is also being investigated for the treatment of other malignancies, including those of the esophagus, lung, and stomach.

Superficial Bladder Cancer

5-Aminolevulinic Acid Hydrochloride can be used to treat early-stage bladder cancer through PDT, which involves the instillation of the drug into the bladder followed by illumination with a laser. This approach aims to destroy cancer cells while minimizing damage to healthy tissue.

Acne Treatment

Topical formulations of 5-Aminolevulinic Acid Hydrochloride have been developed for the treatment of acne. The drug targets sebaceous glands and induces porphyrin production, which upon light activation, helps reduce inflammation and destroy bacteria within the sebaceous follicles.

 

Frequently Asked Questions

 

Q: How does 5-Aminolevulinic Acid Hydrochloride work in Photodynamic Therapy (PDT)?

A: In PDT, 5-Aminolevulinic Acid Hydrochloride acts as a photosensitizer, which means it is a substance that becomes activated when exposed to light. When applied or ingested, ALA Hydrochloride is absorbed by cells and converted into protoporphyrin IX – a precursor to heme.

Q: What are the common side effects of treatment with 5-Aminolevulinic Acid Hydrochloride?

A: The side effects of treatment with 5-Aminolevulinic Acid Hydrochloride can vary depending on the route of administration and the condition being treated. Common side effects include pain and burning at the site of application or injection, swelling, and redness. Patients undergoing PDT with ALA Hydrochloride are particularly advised to avoid direct sunlight or bright artificial light for at least 48 hours after treatment to prevent phototoxic reactions, which can cause severe sunburn-like symptoms.

Q: How is 5-Aminolevulinic Acid Hydrochloride used in the diagnosis of cancers?

A: 5-Aminolevulinic Acid Hydrochloride can be utilized as a diagnostic agent in the field of oncology due to its property of selectively accumulating in malignant cells. In procedures such as fluorescence-guided resection (FGR), ALA Hydrochloride is administered to the patient prior to surgery. Malignant tissues absorb the drug and convert it into protoporphyrin IX, which fluoresces under blue light.

Q: Is 5-Aminolevulinic Acid Hydrochloride effective in treating acne?

A: Yes, topical formulations of 5-Aminolevulinic Acid Hydrochloride have been developed for the treatment of acne, particularly moderate to severe cases. The mechanism of action in acne is based on the fact that ALA Hydrochloride is a precursor in the heme biosynthesis pathway, which is active in the sebaceous glands. When applied to the skin, ALA Hydrochloride penetrates the hair follicles and is converted into protoporphyrin IX.

Q: What role does 5-Aminolevulinic Acid Hydrochloride play in the treatment of neurological disorders?

A: While the primary use of 5-Aminolevulinic Acid Hydrochloride is in PDT and diagnostic procedures, there is emerging research exploring its potential role in the treatment of neurological disorders. The rationale behind its use in conditions such as Alzheimer's disease and multiple sclerosis is based on its involvement in cellular energy metabolism and its antioxidant properties.

Q: Is there a link between 5-Aminolevulinic Acid Hydrochloride and wound healing?

A: Preliminary research suggests that 5-Aminolevulinic Acid Hydrochloride may have a role in promoting wound healing. The exact mechanisms are not entirely clear, but it is thought that ALA Hydrochloride may stimulate angiogenesis, the formation of new blood vessels, which is crucial for delivering nutrients and oxygen to the wound area. Additionally, it may enhance collagen synthesis, which is important for the strength and integrity of the healing tissue.

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