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Co-Enzyme Q10 is a naturally occurring fat-soluble vitamin-like quinone commonly known as CoQ10. It is also called ubiquinone as it is ubiquitous or present in all eukaryotic cells. Chemically coq10 is 2, 3 dimethoxy–5 methyl–6 decaprenyl benzoquinone. The functional group is the quinone ring. By reduction of the quinone to quinol (H2 CoQ10) a carrier of protons and electrons is produced.
Yellow or orange crystalline powder
Product should be preserved in tightly closed containers protected from light, heat, and air. Do not expose to alkalis or strong oxidizing agents
3.Mechanism of action (MOA)
In cardiovascular diseases:Improvement of cardiac bioenergetics Direct free radical scavenger and antioxidant effect Correction of coenzyme Q10 deficiency state Improved endothelial function and vasodilatory effect.
Direct membrane-stabilizing activity due to phospholipid–protein interactions Preservation of myocardial Na+–K+ ATPase activity Stabilization of integrity of Ca2+- dependent slow channels Correction of mitochondrial “leak” of electrons during oxidative respiration Induction of DT diaphorase Possible effects on prostaglandin metabolism Antiviscosity effect .
The dosage of CoQ10 used in clinical trials has evolved over the past 20 years.
Capsules/tablets comes in different dosage formations: 25mg, 30 mg, 50 mg, 75 mg, and 100mg.
• Congestive Heart Failure (CHF): 50 – 100 mg in two or three divided doses.
• Mitochondria Disorders: 400 – 600mg/day in divided doses.
▪ Coenzyme Q10 deficiency: 150mg/day.
▪ Migraines prophylaxis: 150mg/day.
▪ Gum disease: 25 mg two times a day.
• Parkinson Disease: 1200mg/day.
■ Coenzyme Q10 is tolerated well and safe.
■ However, it can cause some mild side effects including :
Stomach upset, loss of appetite, nausea, and diarrhea.
■ It also might lower blood pressure, so it is recommended to monitor blood pressure closely of those with low blood pressure.
■ Dividing the total daily dose into two or three smaller doses a day can help reduce side effects.
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