Coenzyme q10 Skin

1.Introduction

Co-Enzyme Q10 is a naturally occurring fat-soluble vitamin-like quinone commonly known as CoQ10. It is also called ubiquinone as it is ubiquitous or present in all eukaryotic cells. Chemically coq10 is 2, 3 dimethoxy–5 methyl–6 decaprenyl benzoquinone. The functional group is the quinone ring. By reduction of the quinone to quinol (H2 CoQ10) a carrier of protons and electrons is produced.

2.Specification

3.Mechanism of action (MOA)

In cardiovascular diseases:Improvement of cardiac bioenergetics Direct free radical scavenger and antioxidant effect Correction of coenzyme Q10 deficiency state Improved endothelial function and vasodilatory effect.

Direct membrane-stabilizing activity due to phospholipid–protein interactions Preservation of myocardial Na+–K+ ATPase activity Stabilization of integrity of Ca2+- dependent slow channels Correction of mitochondrial “leak” of electrons during oxidative respiration Induction of DT diaphorase Possible effects on prostaglandin metabolism Antiviscosity effect .

4.Dosage

The dosage of CoQ10 used in clinical trials has evolved over the past 20 years.

Capsules/tablets comes in different dosage formations: 25mg, 30 mg, 50 mg, 75 mg, and 100mg.

• Congestive Heart Failure (CHF): 50 – 100 mg in two or three divided doses.

▪ HTN: 75-360mg/day in divided doses.

• Mitochondria Disorders: 400 – 600mg/day in divided doses.

▪ Coenzyme Q10 deficiency: 150mg/day.

▪ Migraines prophylaxis: 150mg/day.

▪ Gum disease: 25 mg two times a day.

• Parkinson Disease: 1200mg/day.

5.Safety

■ Coenzyme Q10 is tolerated well and safe. 

■ However, it can cause some mild side effects including :

Stomach upset, loss of appetite, nausea, and diarrhea. 

■ It also might lower blood pressure, so it is recommended to monitor blood pressure closely of those with low blood pressure. 

■ Dividing the total daily dose into two or three smaller doses a day can help reduce side effects.

6.Feature&Advantage

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