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1.Introduction
Co-Enzyme Q10 is a naturally occurring fat-soluble vitamin-like quinone commonly known as CoQ10. It is also called ubiquinone as it is ubiquitous or present in all eukaryotic cells. Chemically coq10 is 2, 3 dimethoxy–5 methyl–6 decaprenyl benzoquinone. The functional group is the quinone ring. By reduction of the quinone to quinol (H2 CoQ10) a carrier of protons and electrons is produced.
2.Specification
Name | COENZYME Q10 |
Other Names | Ubiquinon |
CAS NO. | 303-98-0 |
EINECS No. | 206-147-9 |
MF | C59H90O4 |
Appearance | Yellow or orange crystalline powder |
Test Method | HPLC UV |
Shelf life | 2 Years |
Storage | Product should be preserved in tightly closed containers protected from light, heat, and air. Do not expose to alkalis or strong oxidizing agents |
3.Mechanism of action (MOA)
In cardiovascular diseases:Improvement of cardiac bioenergetics Direct free radical scavenger and antioxidant effect Correction of coenzyme Q10 deficiency state Improved endothelial function and vasodilatory effect.
Direct membrane-stabilizing activity due to phospholipid–protein interactions Preservation of myocardial Na+–K+ ATPase activity Stabilization of integrity of Ca2+- dependent slow channels Correction of mitochondrial “leak” of electrons during oxidative respiration Induction of DT diaphorase Possible effects on prostaglandin metabolism Antiviscosity effect .
4.Dosage
The dosage of CoQ10 used in clinical trials has evolved over the past 20 years.
Capsules/tablets comes in different dosage formations: 25mg, 30 mg, 50 mg, 75 mg, and 100mg.
• Congestive Heart Failure (CHF): 50 – 100 mg in two or three divided doses.
▪ HTN: 75-360mg/day in divided doses.
• Mitochondria Disorders: 400 – 600mg/day in divided doses.
▪ Coenzyme Q10 deficiency: 150mg/day.
▪ Migraines prophylaxis: 150mg/day.
▪ Gum disease: 25 mg two times a day.
• Parkinson Disease: 1200mg/day.
5.Safety
■ Coenzyme Q10 is tolerated well and safe.
■ However, it can cause some mild side effects including :
Stomach upset, loss of appetite, nausea, and diarrhea.
■ It also might lower blood pressure, so it is recommended to monitor blood pressure closely of those with low blood pressure.
■ Dividing the total daily dose into two or three smaller doses a day can help reduce side effects.
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6.Feature&Advantage
7.Why choose us?
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