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Aescin has numerous pharmacological effects and clinical applications. It can inhibit inflammation, scavenge oxygen free radicals, improve venous tension, inhibit tissue edema, and inhibit cancer progression. , acute lung injury and a variety of tumors treatment and symptom relief effect is obvious.
1 Cerebral thrombosis, cerebral hemorrhage, tuberculous meningitis, acute optic neuritis
Aescin sodium combined with nicardipine can significantly reduce the residual blood volume in the brain and the volume of cerebral edema in patients with hypertensive intracerebral hemorrhage, delay the decrease in blood calcium, significantly reduce the levels of serum creatinine, serum AQP-1, and AQP-4, and promote the Neurological recovery.
2 Cervical radiculopathy, lumbar disc herniation
Aescin improves nerve root and surrounding microcirculation, quickly relieves nerve root swelling, congestion, and aseptic inflammation, and relieves nerve root pain.
3. Gastrointestinal motility disorders related to acute mild pancreatitis, adhesive intestinal obstruction, surgery, etc.
Combined treatment with aescin sodium can significantly reduce nausea and vomiting, abdominal distension and abdominal pain, first defecation, hospital stay, and improve blood amylase, urinary amylase, plasma CRP, and TNF levels, and more effectively inhibit pancreatic enzyme activity and inhibit neutrophils. Cell infiltration and excessive activation of macrophages reduce the release of inflammatory cytokines and improve clinical symptoms.
Aescin can significantly improve sperm density and sperm motility in patients with varicocele, and the improvement rate is roughly the same as that in the surgery group, but aescin only has a significant effect on patients with mild to moderate varicocele.
5 Thyroid disorders
Aescin can significantly reduce the levels of serum thyroid-stimulating hormone (TSH), thyroglobulin antibody (TgAb), thyroglobulin (Tg), and calcitonin, inhibit the progression and recurrence of thyroid cancer, and prolong the progression-free survival of advanced patients. and overall survival, well-tolerated.
6 Acute lung injury, acute phase of chronic obstructive pulmonary disease (COPD)
For patients with COPD in the acute stage, compared with conventional anti-infection, oxygen inhalation, phlegm-reducing and asthmatic treatment alone, the combination of aescin sodium can significantly increase the predicted values of serum SOD, FEV1/FVC, and FEV1%, and increase the predicted value of serum SOD, FEV1/FVC and FEV1% in patients in the acute stage. Serum SOD activity can reduce the levels of MDA and CRP, and improve the lung function of patients. The mechanism may be related to the inhibition of the production of oxidative products in the acute phase and the enhancement of the body's antioxidant capacity.
7 Thrombotic diseases, etc.
Aescin sodium can significantly improve the circumference of the lower extremities in patients with lower extremity deep vein thrombosis, reduce their visual pain score, D-dimer value, improve the clinical symptoms of patients, reduce the dosage of urokinase, and reduce the risk of bleeding.