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Papain is taken from the fruit of the papaya tree. It is used to make medicine. Papain is used for pain and swelling (inflammation) as well as fluid retention following trauma and surgery. It is used as a digestive aid and for treating parasitic worms, inflammation of the throat and pharynx, shingles (herpes zoster) symptoms, ongoing diarrhea, hay fever, runny nose, and a skin condition called psoriasis. Papain is also used along with conventional treatments for tumors.
Some people apply papain directly to the skin to treat infected wounds, sores, and ulcers. In manufacturing, papain is used in cosmetics, toothpaste, enzymatic soft contact lens cleaners, meat tenderizers, and meat products. It is also used for stabilizing and chill-proofing beer. Papain contains substances called enzymes that help break down proteins.
1. Herpes zoster (shingles). Taking papain by mouth might improve some symptoms of shingles.
2. Sore throat and throat swelling (pharyngitis). Taking papain according the suitable papain dosage by mouth, together with other treatments, might relieve sore throat and swelling.
The mechanism by which papain breaks peptide bonds involves the use of a catalytic triad with a deprotonated cysteine. Asn-175 helps to orient the imidazolering of His-159 to allow it to deprotonate the catalytic Cys-25. This cysteine then performs a nucleophilic attack on the carbonyl carbon of a peptide backbone. This forms a covalent acyl-enzyme intermediate and frees the amino terminus of the peptide. The enzyme is deacylated by a water molecule and releases the carboxy terminal portion of the peptide. In immunology, papain is known to cleave the Fc (crystallisable) portion of immunoglobulins (antibodies) from the Fab (antigen-binding) portion. Papain is a relatively heat-resistant enzyme, with an optimal temperature range of 60 and 70 °C.
Papain prefers to cleave at: (hydrophobic)-(Arg or Lys)- cleaves here -(not Val). Hydrophobic is Ala, Val, Leu, Ile, Phe, Trp, or Tyr.
Xi'an Natural Field Bio-Technique Co.,Ltd. as papain manufacturer, which is the professional Manufacturer of Herbal Extract Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. papain extract is the one of strong products, we will supply the best papain supplement price and service to you. If you need this product and related product, please contact us or send an inquiry to [email protected] at any time.