Minoxidil Powder Pharmacological Action and Mechanism——2

2. Promote stoma generation and increase the local blood supply:

Hair growth relies on the vascular network of hair nipples to provide nutrition, in the different growth cycle of hair, the expression of mRNA of vascular endothelial cell growth factor is different, the growth factor mRNA of the hypertherlet cells in the long-term blood vessels is strongly expressed in the dermal nipple cells, but less during the degenerative and rest period.

Experiments show that Minoxidil powder's dose dependence increases the expression of the vascular endothelial cell growth factor mRNA and its proteins, thereby promoting the formation of blood vessels in the dermis and increasing the local blood supply.

3. Open potassium channel:

The opening of potassium channel is an important step to regulate hair growth, animal models of internal and external experiments have shown that Minoxidil is a potassium channel activator, can increase the permeability of potassium ions, prevent calcium ions from flowing into the cells, resulting in a decrease in the concentration of free calcium ions in cells, while calcium ions, epidermal growth factors inhibit hair growth.

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