NMN is known for its ability to delay aging. So, does it really have such an effect?
What is NMN?
NMN (nicotinamide mononucleotide), is a naturally occurring biologically active nucleotide. NMN has two irregular forms, α, and β; the β isomer is the active form of NMN, with a molecular weight of 334.221 g/mol.
NMN is the precursor of NAD+, and its function is mainly reflected through NAD. Therefore, NAD+ should be explained first.
NAD+, also known as coenzyme I, full name Nicotinamide Adenine Dinucleotide, is widely distributed in all cells of the human body and participates in thousands of biocatalytic reactions. It is an essential coenzyme in the human body. Without NAD, the metabolism will not work. The elderly without NAD will suffer from various problems.
Activates the DNA repair pathway PARPs
PARP (poly ADP-ribose polymerase) is a DNA repair enzyme. The study found that PARPS appears to be associated with longevity. Excessive activation of PARP may lead to the decline of cellular NAD+. With the increase of age, the NAD+ content in the human body gradually decreases, and the DNA damage in the nucleus leads to the phenomenon of aging. Whoever has stronger DNA repair ability may have a longer life.
Synthetic NADP+ protects against oxidative damage
NAD+ is catalytically converted into NADH, which helps cells resist oxidative damage.
In addition to this, NADH is also involved in lipid synthesis. During the immune response, in order to kill pathogens, NADH can become a substrate for oxidase, prompting it to induce large amounts of reactive oxygen species to attack pathogens and fight infection.
Activates histone deacetylase sirtuins
Mitochondrial biogenesis
Cellular stress response
Metabolic health
Cell regeneration
Circadian clock
Inflammation reduction
Health Benefits of NAD+ Precursors
With age, the level of NAD+ in the human body tends to decline, so the need for sirtuins, PARPs, and other ways to consume NAD+ may be stronger in the elderly.
Newborn 0-1 year NAD+ mean is 8.54
Adults 30-50 years NAD+ mean value drops to 2.74
Older adults 51-70 years declined to 1.08
In addition, the metabolic syndrome represented by obesity and acute nerve, blood vessel, liver, and kidney damage caused by the bad living habits of modern people may also cause NAD+ deficiency and insufficient sirtuins activity.
Therefore, supplementing the NAD+ level in the body through various precursors can prevent and alleviate many aging-related or acute pathophysiological processes.
NAD+ supplementation can be supplemented in four ways: from food intake, niacinamide, niacin, and NMN. Compared with other NAD+ supplementation methods, it can quickly supplement NAD in the body, which is currently the best and ideal supplementation method. Therefore, NMN supplementation increases the NAD+ content in the body, thereby delaying, improving, and preventing various phenotypes related to aging, age-induced metabolic disorders, etc.
What are the sources of NMN?
NMN is widely distributed in daily food. Vegetables such as cauliflower and Chinese cabbage, fruits such as avocado and tomatoes, and meat such as raw beef are rich in NMN.
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