Dihydromyricetin Powder can inhibit Cladosporium Multicardium and can inhibit mixed flora and molds that cause milk rancidity. In addition, dihydromyricetin has broad-spectrum antibacterial activity against beta-hemolytic streptococcus (ATCC32209), methicillin-resistant Staphylococcus aureus, Candida albicans, Streptococcus pneumonia, and other clinical isolates and other common pathogens. better inhibitory effect.
◆Mechanism of antibacterial action in vitro
The antibacterial process of dihydromyricetin is mainly based on interfering with the proline metabolic pathway of bacteria, which will have a certain impact on the bacterial cell membrane and cell wall, but the target of its effect on bacterial permeability is not in the cell wall. , so the effect on the cell wall is minimal. Different from other natural antibacterial ingredients, compounds with benzene rings and phenolic hydroxyl groups have unique hydrophobic properties, which can temporarily accumulate in the hydrophilic layer of bacterial cell membranes, increasing the intracellular osmotic pressure, and H+ ions are blocked by short-chain organic compounds. The acid is continuously ionized, and after entering the plasma membrane, it will cause certain damage to the activity of the H+-ATPase, resulting in an imbalance of proton kinetic energy. In addition, as a broad-spectrum bacteriostatic agent, dihydromyricetin has very strong hydrophobicity and has many similarities with flavin adenine dinucleotide at the active center site of proline. When dihydromyricetin and citric acid are compounded on the cell membrane, the osmotic pressure of the cell membrane will change, which greatly improves the permeability of the cell membrane; dihydromyricetin is ionized into ions and acts on The hydrophobic active pocket of proline deoxygenase on the plasma membrane affects the metabolic level of proline by competitively inhibiting the activity of other enzymes, resulting in the rapid accumulation of proline in the bacteria, which seriously damages the microbial cells. Good antibacterial effect.
◆The mechanism of antibacterial action in vivo
In the process of preventing and treating MRSA bacteremia infection by dihydromyricetin in vivo, it mainly regulates the expression of the following aspects, including TLR2, MYD88, TNF-α, IL-6, IL-10, IL-1β immunity. Cytokines, etc.; in the body, the number of white blood cells, platelets, red blood cells, and platelet accumulation is regulated. Adopting this method can play a role in strengthening the immune response function of the body and improving the antibacterial ability.
Where to buy Dihydromyricetin Powder Bulk?
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