Nicotinamide mononucleotide ("NMN", "NAMN", and "β-NMN") is a nucleotide derived from ribose and nicotinamide.
[1] In mice, NMN enters cells via the small intestines within 10 minutes converting to NAD+ through the Slc12a8 NMN transporter.
[2] Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.
[3]Dietary supplement companies have aggressively marketed NMN products claiming those benefits.
[4] Doses of up to 500 mg was shown safe in men in a recent human study
[5] at Keio University School of Medicine, Shinjuku, Tokyo Japan. Multiple long-term human studies are underway.
In your body, NMN is converted into NAD +, which is an auxiliary molecule that exists in every cell of your body and supports many aspects of healthy aging.
NAD + metabolism has been proven to be an important part of biochemical reactions and the link between various physiological processes.
Supplementing NAD+ has a significant effect on anti-aging. NMN is also the most eye-catching among all NAD+ precursors.
Because NAD+ molecules are too large to be directly absorbed and the effect is not good, it is recommended to use NMN as a precursor supplement.
NMN nicotinamide mononucleotide improves/prevents various diseases by increasing the level of NAD + in the human body.
NMN is a promising molecule for the treatment of various diseases,
including diabetes, obesity, ischemia-reperfusion injury, heart failure, Alzheimer's disease, retinal degeneration, acute kidney injury, etc.
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