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In this article, We, Xi'an Natural Field Bio-Technique Co.,Ltd. compared the effects of sea buckthorn oil and Centella asiatica extract(Also name gotu kola extract, Hydrocotyle asiatica extract) in the rat model. Twenty-seven female rats were divided into three groups, and two full-thickness wounds were made for each animal. centella asiatica extract ointment was applied topically to Group I. sea buckthorn oil ointment to Group II rats. In Group III, no treatment was applied. On the third day of treatment, wounds on the left side of three animals of each group were excised. On the fifth and eighth day of the treatments, the same procedure was performed for the remaining animals. Indirect immunohistochemical examination was performed to detect transforming growth factor beta (TGF)-beta, endothelial and inducible nitric oxide synthase (eNOS and iNOS), vascular endothelial growth factor, TGF-alpha, laminin, fibronectin, collagen I, and interleukin-1beta.
According to the measurements of the wound areas and wound healing periodo, centella asiatica extract was superior to the control group. Immunohistochemical examinations showed strong (+++) iNOS and TGF-beta immunoreactivities in sea buckthorn oil group. eNOS immunoreactivity was moderate (++) in this group. For the centella asiatica extract group, iNOS, eNOS, and TGF-beta immunoreactivities were moderate (++). In the centella asiatica extract group, while TGF-beta and iNOS immunoreactivities were weaker, laminin and fibronectin reactivities were stronger than in sea buckthorn oil and control groups. Centella asiatica extract was superior to sea buckthorn oil according to the immunohistochemical findings. Centella asiatica extract ointment significantly improves the quality of wound healing and scar formation and is a more appropriate treatment choice than sea buckthorn oil in the early stages of the wound healing process.
Therefore, The centella asiatica extract is the great raw material for wound healing. If you need to know the centella asiatica extract benefits and centella asiatica function, please feel free to contact us or email to email@example.com. We, Xi'an Natural Field Bio-Technique Co.,Ltd. is the professional manufacture for the production of centella asiatica extract.
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