D-Chiro Inositol Powder

Inositol is a natural molecule found in the phospholipids of cell membranes, in the lipoproteins of the plasma and, in the form of phosphate, in the cell nucleus. It has nine forms. Inositol and D-chiro-inositol are most commonly found in supplements.

D-chiro-inositol (DCI) is used for metabolic syndrome and polycystic ovary syndrome (PCOS).

• Mediates the action of insulin;

• It is involved in the synthesis of insulin-dependent androgens;

• Promotes glucose storage;

• Acts as an aromatase modulator.

• Improve insulin resistance and triglycerides in people with metabolic syndrome.

• Improves the oocyte and embryonic quality in women.

• Regulation of cholesterol levels, a more efficient breakdown of fats with a consequent decrease in appetite and weight.

• Decrease blood pressure, and improve blood sugar, ovulation, and pregnancy rates in people with PCOS.

Adults: It is possibly safe for most adults when used for up to 10 weeks (1-4 grams by mouth daily).

Pregnancy: Inositol is possibly safe when taken by mouth, short-term.

Children: Inositol is possibly safe when taken by mouth for up to 12 weeks in children ages 5-12 years old.

Breast-feeding: There isn't enough reliable information to know if inositol is safe to use when breast-feeding. Stay on the safe side and avoid use.

Side Effects: It might cause diarrhea, gas, and nausea in some people.

Note: Speak with a healthcare provider to find out what dose might be best for a specific condition.

1. Myo-inositol and D-chiro inositol, as inositolofosfoglicans, are both "second messengers" of the insulin, but they carry out different functions.

2. Myo-inositol is involved in the transporters activation and the use of glucose, while D-chiro inositol is mainly involved in the glycogen synthesis ans storage.

In the ovaries of a healthy woman, 99% of the inositol intracellular pool is made up of Myo-inositol, while the remaining part is made up of D-chiro-inositol.

Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. Women with PCOS may have infrequent or prolonged menstrual periods or excess male hormone (androgen) levels. The ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs. At ovarian level, myo and d-chiro inositol play different roles:

Myo-inositol mediates glucose uptake and FSH signal (follicle stimulating hormone).

D-chiro-inositol is involved in the insulin-dependent synthesis of androgens and promotes glucose storage.

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