On November 20, Natural Field officially launched the Co-Loading Liposome White Paper. Dr. Duan Ziqing, Head of Co-Loading Liposome Formulation Innovation at Natural Field, delivered an in-depth presentation covering the underlying logic and technical breakthroughs of co-loading liposome technology. The White Paper analyzes four major dimensions-technological innovation, global liposome market trends, multi-scenario application cases, and industrialization pathways-offering a comprehensive interpretation of next-generation liposome delivery systems.
This breakthrough replaces traditional cholesterol with rare ginsenosides as membrane materials, resolving long-standing limitations of liposome loading capacity and stability. Through P-glycoprotein (P-gp) inhibition, the technology dramatically enhances bioavailability and provides a powerful foundation for advanced dietary supplement development.
I. Liposome Technology Enters an Expansion Phase: From Pharmaceuticals to Dietary Supplements
Since its emergence in the 1960s, liposome technology has gradually evolved from laboratory research to large-scale application. In recent years, alongside nanomedicine, liposome delivery systems have entered a period of rapid growth, widely used across pharmaceutics, membrane biology, nano-delivery, food science, and more.
Literature trends indicate a sharp increase in liposome-related research after 2000, particularly in oral delivery and vitamin liposomes. Three major patterns have emerged:
Continued expansion of fundamental research
Delivery targets extending from small-molecule drugs to plant extracts and antioxidants
Application fields expanding from pharmaceuticals into functional nutrition, beauty, and food categories
Liposomes are no longer confined to "complex pharmaceutical formulations," but have become a mainstream delivery solution in functional ingredient development-marking a clear migration of liposome technology from pharmaceuticals to functional nutrition.
II. Co-Loading Liposome Technology: From Single Delivery to Synergistic Formulation
The Co-Loading Liposome White Paper highlights Natural Field's breakthrough Co-Loading Technology, which enables simultaneous encapsulation of multiple active compounds and delivers enhanced synergistic effects.
1) Membrane Material Innovation: From Structural Support to Functional Synergy
Conventional liposomes rely on cholesterol to stabilize the phospholipid bilayer. Natural Field replaces cholesterol with rare ginsenosides (e.g., Rg3, Rh2, Rk1), creating a novel bilayer membrane. These ginsenosides possess intrinsic biological activity-immune modulation, anti-inflammatory activity, and cellular protection-allowing the membrane material itself to contribute to therapeutic synergy.
This "functional membrane" design achieves a 1+1>2 synergistic effect.
2) Superior Thermodynamic Stability
The unique steroidal backbone of rare ginsenosides provides stronger rigidity than cholesterol, significantly improving liposome stability in both gastric environments and long-term storage.
3) Cholesterol-Free Advantage
Traditional cholesterol-based liposomes face restrictions in certain functional food applications and special consumer groups (e.g., those with hyperlipidemia).
The cholesterol-free co-loading liposome breaks these constraints and broadens application potential.
1) CoQ10 Co-Loading Liposome: Dual Improvement in Bioavailability & Anti-Aging Efficacy
Pharmacokinetic data from Caco-2 transport experiments show:
7.86× absorption vs. free CoQ10 (high-dose group)
2.8× absorption vs. standard liposomes
Anti-aging model:
In the D-galactose aging mouse model, the co-loading liposome group significantly restored spleen and thymus index (P<0.001) and markedly elevated IgG and IgM levels, validating its strong anti-immunosenescence potential.
Cardiac protection:
Histopathological analysis showed superior anti-fibrotic effects compared with commercial CoQ10 softgels (P<0.05).
2) Curcumin Co-Loading Liposome: Targeted Enhancement of Anti-Inflammatory Activity
Caco-2 transport testing demonstrated:
8.72× higher transport rate vs. free curcumin
UC inflammation model:
In the DSS-induced ulcerative colitis model, the co-loading liposome group outperformed 10% water-soluble curcumin in restoring colon length and reducing splenic congestion (P<0.05), highlighting strong gut anti-inflammatory potential.
3) Glutathione Co-Loading Liposome: Dual Pathway for Oral & Transdermal Beauty Applications
Data show:
5.33× transport improvement vs. free glutathione
Electron microscopy confirms excellent dispersion, making it suitable for high-end oral beauty as well as premium skincare formulations.
Technology is the moat for raw material suppliers, and data is the passport for brand clients. The Co-Loading Liposome White Paper showcases Natural Field's deep expertise in nano-delivery systems and provides a complete technological pathway from material innovation to formulation optimization.
As functional foods increasingly move toward evidence-based development, co-loading liposome technology is poised to become a core engine of next-generation premium supplements, driving innovation across nutrition, food, and beauty industries.
For the complete technical report, please contact Natural Field to obtain the Co-Loading Liposome White Paper.