What is Glutamine ?
First, you should know l-glutamine is the supplement form of glutamine, the most abundant amino acid in your body. Amino acids also help with a range of biochemicals processes in your body, like the functioning of your immune system, brain, and digestion.
Most glutamine is stored in muscles, followed by the lungs where much of this amino acid is made, according to Mount Sinai. Glutamine is considered a non-essential amino acid because “our body naturally makes it on its own,” says Keri Gans, RD, the author of The Small Change Diet. Still, you can get glutamine from some foods, including chicken, fish, cabbage, spinach, dairy, tofu, lentils, beans, nuts, and mushrooms, says Dana Ellis Hunnes, PhD, MPH, RD, an adjunct assistant professor at the UCLA Fielding School of Public Health.
Glutamine is the most abundant amino acid found in the body. It's made in the muscles and transferred by the blood into different organ systems.It is a building block for making proteins in the body, and it is needed to make other amino acids as well as glucose. Glutamine supplements may assist with gut and immune function, and other processes, especially in times of stress when the body uses more glutamine.
People take it for a load of reasons including. Glutamine is involved in various energy metabolism. By removing oxygen free radicals and antioxidation, it can play a role in enhancing immunity and resisting foreign infections, including bacteria, viruses, protozoa and other invasion. At the same time, it can also promote the recovery of brain function and improve brain function.
What are the benefits of l-glutamine powder ?
This standard applies to food additive L-glutamine, the product in food processing as a nutritional supplement, flavor supplement. And L-glutamine is an important nutritional supplement for bodybuilding sports and bodybuilding enthusiasts. It (hereafter referred to as glutamine) is the most abundant free amino acid in muscle, accounting for about 60% of the total free amino acids in the human body. Fasting plasma glutamine concentrations ranged from 500 to 750umol/L. "Glutamine is not an essential amino acid; it is synthesized in the body from glutamic acid, arginine, and isoleucine." Under stress conditions such as disease, poor nutritional status or high-intensity exercise, the body's demand for glutamine increases so that its own synthesis cannot meet the demand. Glutamine has many effects on the body:
1. Grow muscle, mainly through the following aspects to achieve:
It can provide essential nitrogen source for the body and promote protein synthesis in muscle cells. It can promote the growth and differentiation of muscle cells through cell capacitation. It stimulates the secretion of growth hormone, insulin and testosterone and puts the body in a synthetic state.
2. Glutamine has a potent effect.
Increase strength and endurance. During exercise, body fluids are acidified by the increase in acidic metabolites in the body. "Glutamine has the potential to produce bases, thereby reducing, to some extent, the reduction in exercise capacity or fatigue caused by acids."
3. An important fuel for the immune system, which can enhance the function of the immune system.
Glutamine plays an important role in immune regulation. It is necessary for the secretion, proliferation and maintenance of lymphocyte function. As a precursor and main energy source of nucleic acid biosynthesis, glutamine can promote the mitosis, differentiation and proliferation of lymphocytes and macrophages, increase the production of cytokines such as TNF and IL-1, and increase the mRNA synthesis of phospholipids. The provision of exogenous glutamine can significantly increase the total number of lymphocytes, T lymphocytes and circulating CD4/CD8 ratio in critically ill patients, and enhance the body's immune function.
4. It is involved in the synthesis of glutathione, an important antioxidant.
5. The basic energy source of the luminal cells of the GI tract.
Maintenance of the structure and function of the intestinal barrier: glutamine is an essential nutrient for the metabolism of intestinal mucosal cells and plays a very important role in maintaining the integrity of the intestinal mucosal epithelial structure. Especially under severe stress such as trauma, infection and fatigue, glutamine in intestinal mucosal epithelial cells is rapidly depleted. When the intestine lacks stimulation such as food, digestive juice or glutamine, the intestinal mucosa atrophy, villi become thinner, shorter or even shed, cryps become shallow, intestinal mucosal permeability increases, and intestinal immune function is impaired. Clinical practice has proved that parenteral glutamine can effectively prevent intestinal mucosal atrophy, maintain normal intestinal mucosal weight, structure and protein content, enhance intestinal cell activity, improve intestinal immune function, and reduce the translocation of intestinal bacteria and endotoxin.
6. Improve brain function.
7. Improve the body's antioxidant capacity.
Glutamine supplementation can improve the antioxidant capacity of the body, stabilize the cell membrane and protein structure, protect the function of important organs such as liver, lung, intestine and immune cells, and maintain the normal function of kidney, pancreas, gallbladder and liver by maintaining and increasing the reserve of GSH in tissues and cells.
8. Glutamine-enriched nutritional support can improve the body's metabolism, nitrogen balance, promote protein synthesis, and increase the total number of lymphocytes.
Improve the body's metabolic status: glutamine has a positive role in promoting protein metabolism.
9. Glutamine can maintain intestinal permeability in patients with severe pancreatitis, reduce the occurrence of intestinal bacterial translocation, inhibit the release of inflammatory mediators, reduce the degree of stress response, and shorten the length of hospital stay.
10. Timely and appropriate supplementation of glutamine can effectively prevent the breakdown of muscle protein, and can increase the volume of cells and promote muscle growth through the hydration of cells.
Glutamine is also one of the few amino acids that can promote growth hormone release. Studies have shown that oral administration of just 2 g of glutamine can increase growth hormone levels fourfold, resulting in increased insulin and testosterone secretion and thus enhanced muscle synthesis.
Studies have shown that timely and appropriate supplementation of glutamate can effectively prevent muscle protein breakdown.
Other studies have suggested that glutamine has the effect of aggregating muscle glycogen.
Does l-glutamine cause any side effects?
Does l-glutamine cause any side effects?
L-Glutamine is typically taken in the form of a pill or powder. Generally, it is recommended to start with a smaller dose and increase it slowly as needed. Most people should take between 2 and 40 grams per day, split into two or three daily doses. It is best to take the supplement on an empty stomach, as food may interfere with its absorption.
In general, l-glutamine is considered a “very safe” supplement, Hunnes says. However, she says, there is a chance of having the following side effects:
- Bloating
- Nausea
- Dizziness
- Reflux
- Stomach pain
Keep in mind, per Hunnes, that people with liver disease shouldn’t use l-glutamine because it can cause an altered mental status in these patients. “Also, it's not recommended in people who have bipolar disorder, people who are sensitive to MSG (monosodium glutamate), or who have seizure disorders—it may increase the likelihood of seizure,” she says.
How much l-glutamine should you take?
[Indications] for the treatment of gastric and duodenal ulcers, gastritis, and hyperacidity, and also for the improvement of brain function.
[Dosage and usage] Oral: 1.5-2g/d, combined with neutralizing gastric acid drugs can improve the efficacy. It is used to improve the brain function of children with mental retardation, mental disorders, alcoholism, epilepsy, 0.1-0.72 g per day.
Overall, L-Glutamine is an essential amino acid that is found naturally in some foods and can also be taken as a supplement. It is beneficial for muscle growth and repair, and also helps to support immune system health, to improve energy levels and to reduce cravings caused by stress. It is important to follow the recommended dosage and to speak with a doctor before taking the supplement.
How do you choose an l-glutamine supplement?
l-glutamine powder is harmless in moderation. l-glutamine is a nitrogenous organic acid L-glutamine is widely found in nature, For example, the N-ethyl compound (theanine) is found free in pumpkin and sunflower seedlings and in tea leaves. Although glutamine can be extracted from natural products, fermentation and synthesis are used for mass production. It is important to note that we should not eat too much, otherwise it will increase the burden of the kidney. Used as nutritional supplement, seasoning and fragrance enhancer. It is used in medicine to treat ulcer of digestive organs, alcohol poisoning and improve brain function. l-glutamine must be consumed according to the instructions. Of course, we must choose companies that have passed various certification and testing, such as our company.
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