Osthol is a prenylated coumarin which is abundant in the fruits of Cnidium monnieri Cusson (Umbelliferae). Osthole has a variety of biological activities, including anti-inflammatory, neuroprotective and other effects. In this article, we will examine the role of osthole in the whitening effect.
Mechanism
Inhibitory effect of Cnidium extract on skin melanin formation.
The main mechanism of the skin lightening effect is thought to be the inhibition of the expression of tyrosinase-related genes.
Cnidium is a kind of cosmetic used for skin whitening, which is safe and has no side effects, and has the activity of inhibiting melanin production, especially the whitening effect is very significant. Osthole aids in skin lightening, relieves skin irritation, is stable under UV light conditions, and can be used as a functional ingredient in cosmetic formulations.
Skin melanin production is a defense mechanism against the stimulation of melanocytes by ultraviolet rays, etc., the production of melanin increases, and a large amount of melanin is transferred to the keratinocytes accumulated in the epidermal layer of the skin. While melanin protects the skin, hyperpigmentation of the skin can lead to blemishes, freckles, post-inflammatory skin darkening, and age spots.
The production process of melanin is made by the conversion of tyrosinase to dopa and dopaquinone followed by non-enzymatic oxidation. To relieve and prevent melanosis, substances that inhibit melanin production, such as arbutin, kojic acid, glutathione and osthole, have been developed.
Conclusion
Cnidium reduces melanin pigmentation by inhibiting melanin-producing tyrosinase. Osthole is a promising natural compound in the cosmetic industry.
Where Are You Buying The High Quality Osthole?
Xi'an Natural Field Bio-Technique Co.,Ltd. as osthol powder seller and manufacture, which is the professional Manufacturer of Herbal Extract Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. Osthole is the one of strong products. If you need this products, please contact us and visit their website www.nfnutra.com or send an inquiry to info@natural-field.com at any time.