Apigenin Chamomile

What is Apigenin Chamomile?

Apigenin Chamomile, also known as apigenin, and its chemical name is 4,5,7-Trihydroxyflavone. It is a naturally occurring flavonoid compound widely distributed in a variety of fruits, vegetables, beans, tea, and a variety of Chinese herbal medicines. Known as "phytoestrogens". Its molecular formula is C15H10O5, relative molecular weight is 270.25, insoluble in water, soluble in alcohol, dimethyl sulfoxide, the pure product is light yellow or yellowish-green, and the A phenol ring in its structural formula can be combined with different sugar groups (glucose, Aglycone) combined to show different activities.

Specification:

Apigenin Benefits:

• Apigenin can increase the levels of E-cadherin and Claudin3, while reducing the levels of vimentin and N-cadherin, indicating that apigenin can reverse the increase in EMT marker levels by reducing the expression of Snail and NF-κB, thereby inhibiting PLC And Bel-7402 liver cells invade and migrate.

• Apigenin plays an effect by regulating multiple signal transduction pathways, such as the Wnt/β-catenin pathway, mitogen-activated protein kinases (MAPK) pathway, Notch pathway, PI3K/Akt and NF-κB pathway, and so on.

• Apigenin inhibits the Wnt/β-catenin signaling pathway in human ovarian cells by down-regulating the expression of COX-2, HEF-1, and MMP-2 downstream invasion and metastasis-related proteins, thereby inhibiting cell invasion and metastasis.

• Apigenin can reduce the viability of ANA-1 cells and induce apoptosis in a certain time and concentration-dependent manner; apigenin up-regulates the expression of caspase-3 and caspase-8 and down-regulates the expression of anti-apoptotic protein Bcl-2. The results showed that apigenin-induced apoptosis of ANA-1 cells may be related to the inhibition of the MAPK signaling pathway.

• Apigenin can play an antioxidant role by reducing the generation of oxygen free radicals, scavenging free radicals, and inhibiting lipid peroxidation.

• Apigenin can also play an effect by inducing cell cycle arrest, promoting cell differentiation, enhancing enzyme activity, regulating immunity, and resisting mutations.

Role of apigenin in neurological disorders

Role of apigenin in AD

Studies have shown that apigenin has potential therapeutic effects in AD. Apigenin reduced the production of β-amyloid, alleviated insoluble protein deposition, and attenuated the neurotoxic effects caused by β-amyloid by down-regulating BACE1 levels in the brain of APP/progerin 1 double transgenic AD mice. Apigenin was able to upregulate BDNF expression and restore the extracellular signal-regulated kinase/BDNF signaling pathway to promote neurogenesis and growth and repair damaged neuronal cells, which in turn had a good effect on learning and memory function deficits.

Role of apigenin in PD

Treatment of rat adrenal pheochromocytoma cells (PC12 cells) with MPTP resulted in oxidative stress and a significant increase in apoptosis, indicating that oxidative stress is closely related to apoptosis caused by MPTP neurotoxicity. In contrast, apigenin was able to significantly reduce MPTP-induced oxygen radical production, prevent the decrease of mitochondrial membrane potential, and inhibit neuronal apoptosis in the mitochondrial pathway. both MPTP and rotenone induced PD model mouse brain substantia nigra could reduce the expression levels of glial cell-derived neurotrophic factor (GDNF) and BDNF, triggering motor deficits in model mice, and apigenin was able to significantly upregulate rotenone The expression of GDNF and BDNF in the brain of rotenone induced PD model mice promoted the survival and repair of dopaminergic neurons and motor neurons, and improved the impairment of behavioral activities related to rotational behavior.

Where to buy apigenin?

Apigenin also has a great effect in other aspects, so it is also one of the most popular products. Apigenin powder is our main product, and we have been producing and selling apigenin extract powder for more than ten years. We are the top domestic supplier and manufacturer. Please send the inquiry directly or purchase apigenin via info@natural-field.com