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Melatonin (also known as melatonin, pineal gland) is an amine hormone produced by the pineal gland of mammals and humans. It can brighten a type of melanin-producing cell, hence the name For melatonin. In humans and animals during the day, the light information can be transmitted to the suprachiasmatic nucleus through the retina and optic nerve to inhibit the secretion of melatonin, the content is low, almost undetectable; the secretion at night gradually increases, reaching a peak between 2-4 in the morning. It drops to a very low limit sharply early in the morning. The raw powders melatonin we produce, its main component is melatonin, which can induce natural sleep.
The body's circadian clock pacing point-the suprachiasmatic nucleus of the diencephalon regulates the secretion of melatonin from the pineal gland. Melatonin regulates sleep by activating MT1 and MT2 receptors. The two receptors are members of the G protein-coupled receptor superfamily. It is widely present in the suprachiasmatic nucleus, hippocampus, cerebellar cortex, prefrontal lobe, basal ganglia, substantia nigra ventral tegmental area, nucleus accumbens, etc. of the nervous system, as well as the retina, blood vessels, breast, liver, kidney, and gastrointestinal tract And gonads and other systems in the cell membrane and nucleus. MT1 mainly inhibits neuronal activity and regulates sleep; MT2 mainly induces phase shifts and has the effect of regulating the circadian rhythm.
Functions of Melatonin:
The physiological effects of melatonin, the active ingredient in the raw powders melatonin, melatonin include adjusting the biological clock, inducing sleep, regulating the endocrine system, delaying aging, and enhancing immunity. Among the various regulating effects of melatonin, its regulating effect on sleep is outstanding, and it has obvious effects on sleep disorders caused by sleep delay syndrome and jet lag.
1 Melatonin is effective for circadian rhythm sleep disorders
In patients with sleep disorders caused by circadian rhythm disorders, there is mostly a decrease in melatonin secretion. The application of light and melatonin can effectively treat sleep disorders caused by circadian rhythm disorders, such as delayed sleep phase syndrome, jet lag syndrome, Shift workers, sleep-wake rhythm disorders, non-24h sleep-wake syndrome, etc.
2 Melatonin is effective for insomnia caused by the decrease of melatonin secretion.
With age, melatonin gradually decreases, and the elderly lose Sleep is often caused by this. Melatonin can effectively improve sleep without adverse reactions.
3 Endocrine regulation of melatonin
Melatonin has an obvious sleep-regulating effect. Melatonin can act on the hypothalamus and can significantly reduce the secretion of corticotropin-releasing hormone, which negatively regulates the hypothalamus-pituitary-adrenal axis, reduces the blood cortisol concentration during stress, and improves sleep.
Some research progress of melatonin:
1 The effect of exogenous supplementation of melatonin on the treatment of secondary sleep disorders
Secondary sleep disorders refer to sleep disorders caused by physical diseases, mental diseases, psychological factors, and medication, and insomnia often occurs at the same time as other diseases. Sleep disorders of this type of patient are caused by the disease itself, such as physical or psychological pain, anxiety, etc. The effect is not caused by the decrease of melatonin secretion, and supplementation of exogenous melatonin has no obvious effect on improving sleep. The treatment of such sleep disorders should provide psychological counseling for insomnia while treating the underlying diseases, and further improve sleep based on regulating emotions.
2 The effect of melatonin on the treatment of sleep disorders in patients with Alzheimer's disease (AD)
The MT1 receptor in the suprachiasmatic nucleus of AD patients is sharply reduced, which is only 10% of normal people, which is not enough to exert its normal sleep regulation effect. Therefore, supplementation of melatonin has no obvious effect on sleep rhythm disorders in AD patients.
3 Melatoninergic drugs
3.1 Melatonin long-acting sustained-release tablets
3.4 Melatonin-based health food
Where to buy melatonin?
Natural-Field is one of the best melatonin manufacturers and suppliers. The raw powders melatonin we produce is not only guaranteed in quality, but also at a competitive price! Please contact us directly or purchase melatonin via firstname.lastname@example.org.