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Supplement Ingredients

Paclitaxel

Paclitaxel

Product name: Paclitaxel
Specification: 99.5% HPLC
Appearance: white crysaline powder
CAS No.: 33069-62-4
Certifications: ISO, HACCP, CQC, KOSHER...
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Paclitaxel Details

Product name: Paclitaxel

Specification: 99.5% HPLC

Standard: USP 32

Appearance: white crysaline powder

Mole formular: C47H51NO14 

CAS No.: 33069-62-4

Melting point: 213-216 degree

 

Paclitaxel Oil Introduction

Paclitaxel (PTX) is a chemotherapeutic drug used to treat a variety of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer.

Natural paclitaxel is a mitotic inhibitor for cancer chemotherapy. It was discovered in the National Cancer Institute project of the Research Triangle Institute in 1967, when Monroe E. Wall and Mansukh C. Wani separated it from the bark of the Pacific yew tree (Taxus brevifolia) and named it " Paclitaxel." When it was commercially developed by Bristol-Myers Squibb (BMS), the generic name was changed to "paclitaxel" and the BMS compound was sold under the trademark "TAXOL". In this formulation, paclitaxel was dissolved in Cremophor EL and ethanol as a delivery agent.

Paclitaxel is a natural secondary metabolite isolated from the bark of the gymnosperm yew. It has been clinically proven to have a good anti-tumor effect, especially for ovarian cancer, uterine cancer and breast cancer with high incidence of cancer. Paclitaxel is the most popular anticancer drug on the international market in recent years.


Specification of Paclitaxel

Identification

TLC

Assay by HPLC

99% min.

CAS

33069-62-4

Appearance

White powder

Extract Solvent

Ethanol & water

Loss on Drying

≦2.0%

Ash content

≦0.5%

Residual Solvent

Ethanol<3000ppm

Total Heavy Metals

≤10ppm

As

≤1ppm

Pb

≤1ppm

Hg

≤0.1ppm

Cd

≤1ppm

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g


Main Functions

1. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.

2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.

3. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma. 

4. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.

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