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Natural paclitaxel is a mitotic inhibitor for cancer chemotherapy. It was discovered in the National Cancer Institute project of the Research Triangle Institute in 1967, when Monroe E. Wall and Mansukh C. Wani separated it from the bark of the Pacific yew tree (Taxus brevifolia) and named it " Paclitaxel." When it was commercially developed by Bristol-Myers Squibb (BMS), the generic name was changed to "paclitaxel" and the BMS compound was sold under the trademark "TAXOL". In this formulation, paclitaxel was dissolved in Cremophor EL and ethanol as a delivery agent.
Specification: 99.5% HPLC
Standard: USP 32
Appearance: white crysaline powder
Mole formular: C47H51NO14
CAS No.: 33069-62-4
Melting point: 213-216 degree
Paclitaxel (PTX) is a chemotherapeutic drug used to treat a variety of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer.
Paclitaxel is a natural secondary metabolite isolated from the bark of the gymnosperm yew. It has been clinically proven to have a good anti-tumor effect, especially for ovarian cancer, uterine cancer and breast cancer with high incidence of cancer. Paclitaxel is the most popular anticancer drug on the international market in recent years.
Assay by HPLC
Ethanol & water
Loss on Drying
Total Heavy Metals
Total Plate Count
Total Yeast & Mold
4. Main Functions
1. Paclitaxel powder is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Taxus extract has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4. Natural Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.
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