Estradiol Oil Introduction

Estradiol is a female sex hormone produced by the ovaries, adrenal gland and also the placenta during pregnancy. Estradiol is the most important hormone during a female’s reproductive years, and is required for reproductive and sexual function as well as having an impact on the health of other organs and tissues.

Estradiol mainly promotes the transformation of the endometrium into a proliferative phase and promotes the development of secondary sexual characteristics in women. Therefore, estradiol plays an important role in maintaining female reproductive organs, breast, long bone growth and female sexual characteristics. Estradiol in blood and urine has certain value for endocrine and gynecological diseases such as diagnostic precocity and dysplasia.

Product Name: Estradiol

Specification: 99%

Appearance: White or almost white, odorless powder

CAS Number: 50-28-2 (17 β-Estradiol), 57-91-0 (17-α-Estradiol)

Application

Estrogen drugs for functional bleeding of the uterus, primary amenorrhea, menopausal syndrome, prostate cancer. It can promote and regulate the normal development and accessory characteristics of female sexual organs, and can promote the development of breast ductal hyperplasia, but at higher doses, it can inhibit the release of prolactin in the anterior pituitary, reduce milk secretion, and can also be used Return to the milk. However, there may be nausea, vomiting and excessive proliferation of the endometrium. Patients with liver and kidney dysfunction should be used with caution and should be avoided on the breast, vulva and vaginal mucosa.

Main Functions

Female reproductive growth

In females, estradiol acts primarily as a growth hormone for the reproductive organs including the vagina, the fallopian tubes, the endometrium and the cervical glands. Estradiol also enhances growth of the womb’s muscle layer, the myometrium. In addition, the hormone maintains oocytes (eggs in the ovary) and triggers a series of events that lead to ovulation.

Development of secondary sexual characteristics

The changes that begin around puberty are driven by estradiol. These changes are enhanced during the reproductive age and then become less pronounced after the menopause, as estradiol levels decline. Estradiol is required for normal breast development, alteration of body shape, skin changes, and the fat distribution profile that is typical of females. Estradiol in males is produced by the Sertoli cells of the testes.

Estradiol during menstrual cycle

Estradiol is needed to maintain the eggs inside a female’s ovaries. During the menstrual cycle, follicles on the ovaries secrete estradiol, which triggers a series of events that lead to a surge in luteinizing hormone and, in turn, induces ovulation. This phase of the cycle is referred to as the follicular phase. After ovulation, during the luteal phase, estradiol works in conjunction with progesterone to prepare the womb lining for implantation.

Estradiol during pregnancy

Study reveals link between estrogen and infertility

During pregnancy, the estradiol level rises because it is also produced by the placenta. Estradiol is also thought to play a role in maintaining the pregnancy and research is currently ongoing into the role of estrogens in initiating labor.

Estradiol in bone health

A healthy estradiol is also needed to support adequate bone growth and maintain the health of bones and joints. Estradiol also has an impact on bone structure and oteopenia and osteoporosis can occur if levels of this hormone are low. Bone loss can be accelerated in women of post-menopausal age, who may have a relative deficiency in estradiol.

Effects on the brain

Estradiol function is also produced in the brain and estrogens have been shown to have neuroprotective effects.

Effects on blood flow

Estrogens can exert effects on the vasculature and have been shown to improve blood flow in the coronary arteries.

Involvement in disease

Some research suggests that estrogen activates certain cancer causing genes called oncogenes that raise the risk of breast cancer and endometrial cancer. Estrogens are also involved in several non-cancerous conditions including endometriosis, uterine fibroids and uterine bleeding.

Advantage

1.Promote endometrial hyperplasia.

2. Enhance the contraction of uterine smooth muscle.

3.Promote the development of breast duct hyperplasia, but a larger dose can inhibit the release of prolactin in the anterior pituitary, thereby reducing milk secretion.

4.Anti-androgenic effects.

5.Lower blood cholesterol, and can increase the deposition of calcium in the bone.