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Supplement Ingredients

Docetaxel

Docetaxel

Product name: Decetaxel
Specification: 99.5% HPLC
Appearance: white crysaline powder
CAS No.: 114977-28-5
Standard: GB, USP, EP
Certifications: ISO, HACCP, KOSHER, HALAL
Delivery: Shipped in Same day from stocks
Carton:1-10kg
Drum: 20,25kg
Pallet:12drums/pallet,or 30cartons/pallet
Storage: Well-closed, dry place with constant 2-8℃
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1.Introduction


Docetaxel is a drug synthesized on the basis of chemicals in yew trees.Docetaxel (DTX) is a chemotherapeutic drug for the treatment of a variety of cancers, including breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small cell lung cancer. It can be used alone or in combination with other chemotherapeutic drugs, by slow injection into the vein.Common side effects include hair loss, low blood count, numbness, shortness of breath, vomiting and muscle aches. The mechanism of action of this drug is similar to paclitaxel, which inhibits depolymerization of microtubules and inhibits cell division. 


2.Mechanism of Action 


The mechanism of action of docetaxel is mainly in microtubules. Microtubules are prepared by polymerizing tubulin. Tubulin is a protein with a molecular weight of 100,000 kDa and consists of two polypeptide subunits of alpha and beta. There is a dynamic balance between the polymerization of tubulin and the depolymerization of microtubules. Docetaxel accelerates the polymerization of tubulin into microtubules and delays the depolymerization of microtubules, resulting in the formation of stable, non-functional microtubule bundles that disrupt mitosis and cell proliferation.


3.Specification 



Identification

TLC

Assay by HPLC

99% min.

Appearance

White powder

Extract Solvent

Ethanol & water

Loss on Drying

≦2.0%

Ash content

≦0.5%

Residual Solvent

Ethanol<3000ppm

Total Heavy Metals

≤10ppm

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g


4.Function


■ anti-cancer activity against a variety of tumors, including breast cancer, non-small cell lung cancer, and other malignancies (prostate cancer, esophageal cancer, and head and neck cancer). 

■ Studies have shown that docetaxel may be one of the most effective monotherapy for metastatic breast cancer. Of particular note, docetaxel is perhaps the most active drug in the treatment of metastatic breast cancer, and it is currently the most effective single-agent chemotherapy for advanced breast cancer. 


5.Feature&Advatage



53powder(1)


6.Why choose us?



quality assurance


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