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Docetaxel is a drug synthesized on the basis of chemicals in yew trees.Docetaxel (DTX) is a chemotherapeutic drug for the treatment of a variety of cancers, including breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small cell lung cancer. It can be used alone or in combination with other chemotherapeutic drugs, by slow injection into the vein.Common side effects include hair loss, low blood count, numbness, shortness of breath, vomiting and muscle aches. The mechanism of action of this drug is similar to paclitaxel, which inhibits depolymerization of microtubules and inhibits cell division.
2.Mechanism of Action
The mechanism of action of docetaxel is mainly in microtubules. Microtubules are prepared by polymerizing tubulin. Tubulin is a protein with a molecular weight of 100,000 kDa and consists of two polypeptide subunits of alpha and beta. There is a dynamic balance between the polymerization of tubulin and the depolymerization of microtubules. Docetaxel accelerates the polymerization of tubulin into microtubules and delays the depolymerization of microtubules, resulting in the formation of stable, non-functional microtubule bundles that disrupt mitosis and cell proliferation.
Assay by HPLC
Ethanol & water
Loss on Drying
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■ anti-cancer activity against a variety of tumors, including breast cancer, non-small cell lung cancer, and other malignancies (prostate cancer, esophageal cancer, and head and neck cancer).
■ Studies have shown that docetaxel may be one of the most effective monotherapy for metastatic breast cancer. Of particular note, docetaxel is perhaps the most active drug in the treatment of metastatic breast cancer, and it is currently the most effective single-agent chemotherapy for advanced breast cancer.
6.Why choose us?