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Supplement Ingredients

Docetaxel

Docetaxel

Product name: Decetaxel
Specification: 99.5% HPLC
Appearance: white crysaline powder
CAS No.: 114977-28-5
Certifications: ISO, HACCP, CQC, KOSHER
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Docetaxel Details

Product name: Docetaxel

Specification: 99.5% HPLC

Standard: USP 38

Mole formular: C43H53NO14

CAS No.:  114977-28-5

Appearance: white crysaline fine powder

 

Docetaxel Oil Introduction

Docetaxel (DTX) is marketed under the trademarks Taxotere and is a chemotherapeutic drug for the treatment of a variety of cancers, including breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small cell lung cancer. It can be used alone or in combination with other chemotherapeutic drugs, by slow injection into the vein.

Common side effects include hair loss, low blood count, numbness, shortness of breath, vomiting and muscle aches. Other serious side effects include allergic reactions and future cancer. Side effects are more common in patients with liver problems, and use during pregnancy can harm your baby. Docetaxel is a taxane that acts to disrupt the normal function of microtubules and thereby prevent cell division.

Docetaxel was patented in 1986 and was approved for medical use in 1995. It is the World Health Organization's list of essential medicines and is the most effective and safest medicine required for health systems. Docetaxel can be used as a general-purpose drug. Xi'an Natural Biotechnology Co., Ltd. has a mature production technology, from 10-DAB III to Pacitaxel to docetaxel.

Docetaxel is a drug synthesized on the basis of chemicals in yew trees. The mechanism of action of this drug is similar to paclitaxel, which inhibits depolymerization of microtubules and inhibits cell division. It is indicated for the treatment of locally advanced non-small cell lung cancer or metastatic breast cancer.


Main Functions

Docetaxel has anti-cancer activity against a variety of tumors, including breast cancer, non-small cell lung cancer, and other malignancies (prostate cancer, esophageal cancer, and head and neck cancer). Studies have shown that docetaxel may be one of the most effective monotherapy for metastatic breast cancer. Of particular note, docetaxel is perhaps the most active drug in the treatment of metastatic breast cancer, and it is currently the most effective single-agent chemotherapy for advanced breast cancer. This is the first and only chemotherapy drug in an anthracycline that has proven to be excellent.

The mechanism of action of docetaxel is mainly in microtubules. Microtubules are prepared by polymerizing tubulin. Tubulin is a protein with a molecular weight of 100,000 kDa and consists of two polypeptide subunits of alpha and beta. There is a dynamic balance between the polymerization of tubulin and the depolymerization of microtubules. Docetaxel accelerates the polymerization of tubulin into microtubules and delays the depolymerization of microtubules, resulting in the formation of stable, non-functional microtubule bundles that disrupt mitosis and cell proliferation.


Specification of Docetaxel

Identification

TLC

Assay by HPLC

99% min.

CAS

 114977-28-5

Appearance

White powder

Extract Solvent

Ethanol & water

Loss on Drying

≦2.0%

Ash content

≦0.5%

Residual Solvent

Ethanol<3000ppm

Total Heavy Metals

≤10ppm

As

≤1ppm

Pb

≤1ppm

Hg

≤0.1ppm

Cd

≤1ppm

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g


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