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It is a natural organic compound isolated from the Pacific yew tree (Taxus) and related species.10-DAB III is a white to off white crystalline powder, insoluble in water.
10-DeacetylbaccatinIII or 10-DAB III is a crucial intermediate for Docitaxel, two of the best anti-cancer drugs ever invented. By extracting the pre-cursor 10-DAB III in large quantites from the Taxus baccata leaf, many subsequent semiayntheses can be carried out. The esterification of 10-DAB III also causes an enhancement in the kinetics, and therefore the pharmacological profile of these important chemo-therapeutic agents.
Assay by HPLC
Ethanol & water
Loss on Drying
Total Heavy Metals
Total Plate Count
Total Yeast & Mold
Anti-Cancer for drug raw material.
■ 10-DAB is used as the core starting material in the semi-synthetic manufacturing of paclitaxel .
Paclitaxel is a commonly used anticancer drug in clinical practice. There are 2 synthetic methods, total synthesis and semi-synthesis. Total synthesis cannot be commercially produced due to many steps, low yield, harsh reaction conditions and other high costs.10-DAB is an important raw material for the synthesis of paclitaxel by semi-synthetic pathway.
■ 10-DAB is also used as the starting raw material for docetaxel , a potent anticancer compound.
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