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Supplement Ingredients

10-deacetylbaccatin Iii (10-dab)

10-deacetylbaccatin Iii (10-dab)

Product name: 10-DAB III
Specification: 99.5% HPLC
Appearance: white crysaline powder
CAS No.: 32981-86-5
Certifications: ISO, HACCP, CQC, KOSHER
Feature: Natural Field Production Patent
Delivery: Shipped in Same day from stocks
Carton:1-10kg
Drum: 20,25kg
Pallet:12drums/pallet,or 30cartons/pallet
Storage: Well-closed, dry place with constant 2-8℃
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1.Introduction


It is a natural organic compound isolated from the Pacific yew tree (Taxus) and related species.10-DAB III is a white to off white crystalline powder, insoluble in water.

 10dab

10-DeacetylbaccatinIII or 10-DAB III is a crucial intermediate for Docitaxel, two of the best anti-cancer drugs ever invented. By extracting the pre-cursor 10-DAB III in large quantites from the Taxus baccata leaf, many subsequent semiayntheses can be carried out. The esterification of 10-DAB III also causes an enhancement in the kinetics, and therefore the pharmacological profile of these important chemo-therapeutic agents.


2.Specification 



Identification

TLC

Assay by HPLC

99% min.

CAS

32981-86-5

Appearance

White powder

Extract Solvent

Ethanol & water

Loss on Drying

≦2.0%

Ash content

≦0.5%

Residual Solvent

Ethanol<3000ppm

Total Heavy Metals

≤10ppm

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g


3.Function


Anti-Cancer for drug raw material.

■ 10-DAB is used as the core starting material in the semi-synthetic manufacturing of paclitaxel .

Paclitaxel is a commonly used anticancer drug in clinical practice. There are 2 synthetic methods, total synthesis and semi-synthesis. Total synthesis cannot be commercially produced due to many steps, low yield, harsh reaction conditions and other high costs.10-DAB is an important raw material for the synthesis of paclitaxel by semi-synthetic pathway.

■ 10-DAB is also used as the starting raw material for docetaxel , a potent anticancer compound.


4.Feature&Addvatnage


53powder(1)

5.Why choose us?



quality assurance



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