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1.Introduction
It is a natural organic compound isolated from the Pacific yew tree (Taxus) and related species.10-DAB III is a white to off white crystalline powder, insoluble in water.
10-DeacetylbaccatinIII or 10-DAB III is a crucial intermediate for Docitaxel, two of the best anti-cancer drugs ever invented. By extracting the pre-cursor 10-DAB III in large quantites from the Taxus baccata leaf, many subsequent semiayntheses can be carried out. The esterification of 10-DAB III also causes an enhancement in the kinetics, and therefore the pharmacological profile of these important chemo-therapeutic agents.
2.Specification
Identification | TLC |
Assay by HPLC | 99% min. |
CAS | 32981-86-5 |
Appearance | White powder |
Extract Solvent | Ethanol & water |
Loss on Drying | ≦2.0% |
Ash content | ≦0.5% |
Residual Solvent | Ethanol<3000ppm |
Total Heavy Metals | ≤10ppm |
Total Plate Count | ≤1000cfu/g |
Total Yeast & Mold | ≤100cfu/g |
3.Function
Anti-Cancer for drug raw material.
■ 10-DAB is used as the core starting material in the semi-synthetic manufacturing of paclitaxel .
Paclitaxel is a commonly used anticancer drug in clinical practice. There are 2 synthetic methods, total synthesis and semi-synthesis. Total synthesis cannot be commercially produced due to many steps, low yield, harsh reaction conditions and other high costs.10-DAB is an important raw material for the synthesis of paclitaxel by semi-synthetic pathway.
■ 10-DAB is also used as the starting raw material for docetaxel , a potent anticancer compound.
4.Feature&Addvatnage
5.Why choose us?
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