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What is dihydromyricetin (dhm)?
Dihydromyricetin (3,5,7,3,4,5,-hexahydroxy-2,3 dihydromyricetin, referred to as DMY or DHM), was developed by Kotake and Kubota from the genus Neem in 1960 Yeyu grape [Ampelopsis meliaefolia (Hand. -Mazz.) WTWang] was isolated from the leaves for the first time, and was named as ampelopsin. In 1996, Zhou Tianda and others isolated the compound from the stems and leaves of Tengcha, and named it the current name. Studies have shown that the substance has many biological activities such as anti-oxidation, anti-infection, anti-cancer, liver protection, regulating blood lipids and blood sugar. The dihydromyricetin extract we produce is a high-purity raw material with a content of more than 98%.
Where to find dihydromyricetin?
DMY exists in grapes, Myricaceae, Rhododendrons, Garciniaceae, Euphorbiaceae, Salicaceae and other plants, and a large number of them are found in the grape family Snake grapes such as A. grossedentata and feather snake A. chaffanjonii, A. cantoniesis, A. sinica, A. sinica var. hancei, A. brevipedunculata, etc., are widely distributed In my country's Guangdong, Guangxi, Yunnan, Hunan, Hubei, Jiangxi and other provinces. The content of the young stems and leaves of the Snake Snake grape plant can reach 40%, followed by 19.98% in the old leaves, 2.34% in the stems and branches, and a trace amount in the roots. As a natural product, DMY has such a high monomer content in plants, which is rare. It is more advantageous for the extraction of dihydromyricetin extract.
Benefits of Dihydromyricetin:
1 Antioxidant activity
DMY has a good antioxidant effect and potential activity to stimulate cell viability. DMY can significantly inhibit the production of malondialdehyde (MDA) in myocardial, liver, and brain tissue homogenates. When the concentration is 5-20 μmol/L, as the concentration increases, the effect of inhibiting the production of MDA increases. DMY has a significant inhibitory effect on lipoxygenase, with an EC50 of 6.7-74.1 mmol, which can competitively inhibit linoleic acid at the active site of lipoxygenase.
2 Anti-tumor activity
DMY exerts anti-tumor activity by inhibiting tumor cell proliferation, promoting tumor cell death, and inhibiting tumor cell invasion and migration. DMY can effectively inhibit the rapid proliferation of cancer cells, accelerator apoptosis, and slow down the patient's condition, with outstanding curative effect. In addition, DMY may inhibit choriocarcinoma MMP-2mRNA expression through the PI3K/Akt signaling pathway, thereby inhibiting the invasion and metastasis of choriocarcinoma cells and achieving anti-tumor activity.
3 Hypoglycemic and hypolipidemic activity
By using rattan tea leaves as raw materials and using alloxan-induced diabetic mouse models to observe the blood sugar lowering effect of DMY, it was found that DMY had a significant blood sugar lowering effect on hyperglycemia model mice. DMY intervention significantly inhibited the increase in liver index, fasting blood glucose, fasting insulin and blood triglycerides, liver fat accumulation and reduction in liver ATP content induced by high-fat feeding, and significantly antagonized high-fat-induced mitochondrial division and fusion gene mRNA and Changes in protein expression levels.
4 Anti-alcoholic activity
Hase et al. found that the DMY proposed from H. dulcis has the best effect as a detoxifying agent in the experiment of detoxifying alcohol. Then they found that the principle of detoxifying alcohol by DMY is mainly by accelerating the decomposition of ethanol's metabolite, acetaldehyde. It is a harmless substance to protect the liver and reduce the damage of ethanol to the liver.
5 Other functions
In addition, DMY also has antibacterial, anti-inflammatory, analgesic, expectorant and cough-relief, immunity, prevention and treatment of kidney stones, and prevention of neurodegenerative diseases. DMY against Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Aerobacillus, Saccharomyces cerevisiae, Rhodotorula glutinis, Penicillium, Aspergillus niger, Mucor and Rhizopus, Pseudomonas aeruginosa, Type A hemolysis 16 kinds of bacteria such as type streptococcus, beta hemolytic streptococcus, pneumococcus, and streptococcus albicans all have a certain inhibitory effect on growth and reproduction.
Where to buy dhm?
We are a professional supplier and manufacturer of dihydromyricetin extract
1. With nearly 20 years of production experience
2. Strict quality inspection process
3. Advanced production research and development equipment and professional scientific research talents
4. Complete qualification certification
5. Volume with annual sales of over 100 million yuan
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