Emodin Powder 80%,95% Rhubarb Root Extract Details

Emodin Powder 80%,95% Rhubarb Root Extract Oil Introduction

The diaphorus scientific name "1,3,8-trihydroxy-6-methyloxime" exists in the form of free and glycoside in rhizomes and roots of Ranunculaceae, rhubarb and Tangut special rhubarb. It is orange crystal, can be sublimated in vacuum (1,600Pa), soluble in ethanol, sodium hydroxide, sodium carbonate, aqueous ammonia solution, slightly soluble in ether, chloroform, carbon tetrachloride, benzene, almost insoluble in water. Its triacetate is yellow crystal with a melting point of 197 °C. Its 3-methyl ether (also known as emodin methyl ether) is a deep red needle-like crystal with a melting point of 207 ° C and can be extracted by plants or chemically.

Specification of Emodin Powder 80%,95% Rhubarb Root Extract

Main Functions

1. Antitumor activity

Emodin on mouse solid sarcoma S-180, mouse liver cancer, breast cancer, Ehrlich ascites carcinoma, lymphosarcoma,

Melanoma and rat Wacker tumors and lung cancer A-549 have inhibitory effects, and the inhibition rate is above 30%. The inhibition rate of mouse melanoma growth was 73% at a dose of 50 mg/kg day-1; the inhibition rate of mouse breast cancer at a dose of 75 mg/kg day-1 was 45%. Emodin can prolong the survival of P388 leukemia mice with a prolongation rate of more than 40%. One of its mechanisms of action is to inhibit the biosynthesis of DNA, RNA and proteins of cancer cells and inhibit the oxidative dehydrogenation of cancer cells.

2. Antimicrobial growth

Emodin inhibits Staphylococcus aureus 209P, Streptococcus, Diphtheria, Bacillus subtilis, Paratyphoid bacillus, Shigella, Escherichia coli, Influenza, Pneumococci, and catarrhalis; It has a strong inhibitory effect; its MIC is slightly higher than metronidazole, and the concentration of anaerobic bacteria can be inhibited by 76%~91% at 8μg/ml. The antibacterial mechanism of emodin is related to inhibition of mitochondrial respiratory chain electron transport, inhibition of respiration and oxidation and dehydrogenation of amino acid, sugar and protein metabolism intermediates. The final result of inhibiting the synthesis of nucleic acids and proteins inhibits bacterial growth.

3. Immunosuppressive effect

Intraperitoneal injection of emodin at a dose of 70 mg/kg can inhibit the production of rat antibodies, inhibit the clearance of carbon particles, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the phagocytic function of peritoneal macrophages. In vitro, the concentration of [3H]-TdR and [3H]-Urd in lymphocytes at 10 mg/ml was significantly inhibited.

Antispasmodic and antitussive effects

Emodin has a strong inhibitory effect on sputum induced by acetylcholine in isolated rat intestinal tract, which is about 4 times that of papaverine. Emodin also has a significant antitussive effect.

4. The role of the cardiovascular system

Emodin has an excitatory effect on isolated sputum hearts at low doses, while large doses have an inhibitory effect. Emodin also has a hypotensive effect.

5. Diuretic effect

Emodin can increase the content of sodium and potassium in the urine, promote ureteral motility, and increase urine output. Effect on histamine

Administration of emodin to rats with experimental intestinal obstruction at a dose of 10 μg/kg can restore histamine content in rat intestinal mucosa

To normal levels, but no effect on histamine content in the blood.

6. Synthesis of LTB4

Emodin is an inhibitor of 5-lipoxygenase, which inhibits the synthesis of LTB4 in human polynuclear leukocytes and LTB4 in whole blood, and has no inhibitory effect on the synthesis of PGE2.

7. diarrhea

Emodin can inhibit the transport of sodium and potassium ions from the intestinal lumen to the cells, so that the water stays in the intestinal lumen, stimulates the large intestine, promotes its peristalsis, and thus acts as a diarrhea, but the effect is weak.