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Natural Ingredients

Ginsenoside RG3

Ginsenoside RG3

Product Name: Ginseng Extract
CAS No.: 14197-60-5
Appearance: Light yellow or off-white powder
Specification: ginseng rg3 8%,45%, 90%
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Ginsenoside Rg3 Details

Product Name: Ginseng Extract

Latin name: Panax ginseng C. A. Meyer

Used part: Root

CAS No.: 14197-60-5

Appearance: Light yellow or off-white powder

Specification: ginseng rg3 8%,45%, 90%

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Ginsenoside RG3 Oil Introduction

Ginsenoside Rg3 is a saponin extracted from red ginseng and has many effects. The inhibition of ginsenoside Rg3 tumor cells is firstly inhibited by tumor neovascularization. It can be produced in low-dose applications, and is most suitable for preventing tumorigenesis and tumor recurrence and metastasis, and has no common side effects of other anticancer drugs, and can be used for a long time. Rg3 can also inhibit the proliferation and infiltration of tumor tumor cells and induce tumor cell apoptosis in a large dose.


Specification of Ginsenoside Rg3

Identification

TLC

Assay by HPLC

8%, 45%,90% min.

CAS

14197-60-5

Appearance

White or pale yellow powder

Extract Solvent

Ethanol & water

Loss on Drying

≦2.0%

Ash content

≦0.5%

Residual Solvent

Ethanol<3000ppm

Total Heavy Metals

≤10ppm

As

≤1ppm

Pb

≤1ppm

Hg

≤0.1ppm

Cd

≤1ppm

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g


Pharmacological Action

Ginseng has great vitality, nourishing and strong, soothing and sorrowing, Shengjin, Fumai Gutie and other effects. Modern medicine generally believes that ginseng has a wide range of effects on the central nervous system, cardiovascular system, digestive system, immune system, endocrine system, genitourinary system, which can improve the activity of human body and intelligence, and enhance the body's non-specificity to noxious stimuli. resistance. The pharmacological activity of ginseng is often caused by the two-way action of the body's functional state. Therefore, ginseng is a typical representative drug with the function of “adapting to the original”.


Main Functions

1. It can inhibit the proliferation of tumor cells.

2. It can inhibit tumor invasion and metastasis.

Lishi H research found that ginsenoside Rg3 inhibits the infiltration of tumor cells into the basement membrane and surrounding tissues of the vascular wall by inhibiting the synthesis of deoxyribonucleic acid and protein in tumor cells, thereby inhibiting tumor invasion and metastasis. Clinical experiments have shown that the inhibition rate of ginsenoside Rg3 on various solid tumors is 60%, and the inhibition rate of ginsenoside Rg3 on lung cancer metastasis and liver cancer metastasis is 70%-80%. Shinkai et al. demonstrated in vitro anti-infiltration test that ginsenoside Rg3 can significantly inhibit the infiltration of mouse ascites hepatoma cells (MM1), B 16FE7 melanoma, human small cell lung cancer (OC-10) and human pancreatic cancer cells (PSN-1). 

3. Its anti-metastatic effect on tumor cells.

Mochizuki et al. compared the three ginsenosides similar to the mother nucleus extracted from red ginseng in the B16-BL6 melanoma and 26-M3.1 colon adenocarcinoma-induced lung metastasis: 20(R)-ginsenoside Rg3 and 20 (s) - Anti-tumor effect of ginsenoside Rg3 and ginsenoside Rb2. The results showed that 20(R)-ginsenoside Rg3 and 20(s)-ginsenoside Rg3 inhibited the adhesion of B16-BL6 melanoma cells to the basement membrane and inhibited the adhesion and invasion of fibronectin and laminin. And inhibit the formation of neovascularization around the tumor, so it inhibits the lung metastasis of B16-BL6 melanoma (but does not inhibit the change of tumor size), and ginsenoside Rg3 can inhibit the peritoneal metastasis of colorectal adenocarcinoma in Wistar rats, 5mg/ The rate of peritoneal metastasis decreased from 57% to 13% at the kg dose.

4. It can inhibit the proliferation of vascular endothelial cells induced by gastric cancer.

Rg3 inhibits conditioned medium-induced proliferation of vascular endothelial cells in gastric cancer cells. The mechanism may be to reduce the sensitivity of vascular endothelial cells to growth factors secreted by tumor cells by down-regulating the expression of vascular endothelial cell-associated growth factor receptors in proliferating cells, thereby affecting the proliferation of vascular endothelial cells.

5. It can promote the apoptosis of tumor cells.

Ginsenoside Rg3 is the most potent inhibitor of proliferation of human prostate cancer cells, LNCaP and other androgen-dependent tumor cells, and promotes apoptosis by down-regulating the apoptosis-inducing gene Bcl-2 with up-regulation of the apoptosis-promoting gene caspase-3.

6. Pharmacological effects of ginsenoside Rg3.

Ginsenoside Rg3 exerts an anti-tumor effect in the body, mainly through the absorption of intestinal and liver functions.

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