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Natural Ingredients

Apigenin Cancer

Apigenin Cancer

Product name: Apigenin
Alias: celery aglycone
Chemical formula: C15H10O5
Molecular weight 270.2369
CAS number: 520-36-5
Melting point: 347~348℃
Density: 1.548 g/cm³
Appearance: light yellow needle-like crystals
Main functions: anti-oxidation, anti-tumor, etc.
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Apigenin Definition:

Apigenin cancer is a topic of increasing concern. Apigenin, also known as apigenin, and its chemical name is 4,5,7-trihydroxyflavone. It is a naturally occurring flavonoid compound widely distributed in a variety of fruits, vegetables, beans, tea, and a variety of Chinese herbal medicines. Known as "phytoestrogens". Its molecular formula is C15H10O5, relative molecular weight is 270.25, insoluble in water, soluble in alcohol, dimethyl sulfoxide, the pure product is light yellow or yellowish-green, and the A phenol ring in its structural formula can be combined with different sugar groups (glucose, Aglycone) combined to show different activities.

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Apigenin Cancer:

1 Inhibit tumor cell proliferation and induce tumor cell apoptosis. Apoptosis is the process of cell self-death. Apigenin can induce tumor cell apoptosis.

2 Inhibit tumor invasion and metastasis

Apigenin can increase the levels of E-cadherin and Claudin3, while reducing the levels of vimentin and N-cadherin, indicating that apigenin can reverse the increase in EMT marker levels by reducing the expression of Snail and NF-κB, thereby inhibiting PLC And Bel-7402 human liver cancer cells invade and migrate.

3 Interfere with the signal transduction of tumor cells

Apigenin plays an anti-tumor effect by regulating multiple signal transduction pathways, such as the Wnt/β-catenin pathway, mitogen-activated protein kinases (MAPK) pathway, Notch pathway, PI3K/Akt and NF-κB pathway, and so on.

3.1 Wnt/β-catenin signaling pathway

Apigenin inhibits the Wnt/β-catenin signaling pathway in human ovarian cancer cells by down-regulating the expression of COX-2, HEF-1, and MMP-2 downstream invasion and metastasis-related proteins, thereby inhibiting tumor cell invasion and metastasis.

3.2 MAPK signal pathway

Apigenin can reduce the viability of ANA-1 cells and induce apoptosis in a certain time and concentration-dependent manner; apigenin up-regulates the expression of caspase-3 and caspase-8 and down-regulates the expression of anti-apoptotic protein Bcl-2. The results showed that apigenin-induced apoptosis of ANA-1 cells may be related to the inhibition of the MAPK signaling pathway.

4 Reverse the drug resistance of tumor cells and increase the sensitivity of chemotherapeutics

Under the action of apigenin, the retention rate of Rhodamine-123 in breast cancer multidrug-resistant cells MCF-7/ADR increases, and the efflux decreases; with the increase of apigenin concentration, the P in MCF-7/ADR -GP protein expression and mRNA of the MDR1 gene continue to decrease. The results of the study showed that the reversal multiple of apigenin on ADR in MCF-7/ADR was 3.22, and the results showed that apigenin has the effect of reversing the multidrug resistance of breast cancer MCF-7/ADR cells.

5 Antioxidant effect

Apigenin can play an antioxidant role by reducing the generation of oxygen free radicals, scavenging free radicals, and inhibiting lipid peroxidation.

6 other

Apigenin can also play an anti-tumor effect by inducing tumor cell cycle arrest, promoting tumor cell differentiation, enhancing enzyme activity, regulating immunity, and resisting mutations.

apigenin cancer

Where to buy apigenin?

In addition to apigenin cancer, it also has a great effect in other aspects, so it is also one of the most popular products. Apigenin powder is our main product, and we have been producing and selling apigenin extract powder for more than ten years. We are the top domestic supplier and manufacturer. Do you need to buy apigenin to research or treat cancer? Please send the inquiry directly or purchase apigenin via info@natural-field.com

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