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Paclitaxel is a kind of natural secondary metabolite separated and purified from the bark of gymnosperms taxol, which is the most excellent natural anticancer drug found in today's society. This product is white or white-like crystalline powder.This product is soluble in methanol, ethanol or trichloromethane, slightly soluble in ether, almost insoluble in water.The extraction process of paclitaxel is generally methanol or ethanol extraction, after ethane degrease, dichloromethane or trichloromethane extraction products.
In 1963, American chemists first isolated the crude extract of paclitaxel from the bark and wood of a species of Pacific fir growing in the great forests of the Western United States.In the screening experiment of Taxus chinensis, it was found that the crude extract of paclitaxel had high activity to mouse tumor cells cultured in vitro, and the active ingredient was isolated.
Because the active ingredient is so low in plants, it wasn't until 1971 that they teamed up with Duke University chemistry professor Jon M. to determine the chemical structure of the active ingredient, a tetracyclic diterpene compound, by X-ray analysis and named it Paclitaxel.
Paclitaxel anti-cancer activity as a diterpene alkaloids compounds, its chemical structure is very complex and drug molecules are eleven extensive and significant biological activity, mechanism of action and unique, scarce natural resources makes it by botanists, a chemist, a pharmacologist, molecular biologists have great favour, make it a remarkable anticancer star in the second half of the 20th century and the research focus.Through clinical verification, it has a good anti-tumor effect, especially for ovarian cancer, uterine cancer and breast cancer with a high incidence of cancer.Paclitaxel is one of the most popular anticancer drugs in the international market in recent years and is considered to be one of the most effective anticancer drugs in the next 20 years.
If you need wholesale paclitaxel or for any inquiry or further information, welcome to contact [email protected]. Natural Field Ltd. would always provide you an all-in-one solution.