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The History of Minoxidil
Oct 31, 2019

Minoxidil was the first potassium channel opener introduced in the 1960s, with strong dilating blood vessels, mainly used to treat severe, stubborn hypertension. Clinically, minoxidil powder has been used for many years, and one of its side effects is that it causes hairy disorder after oral administration.


As early as the early 1980s, some hospitals used this side effect to crush minoir tablets and dissolve them with appropriate solvents to make locally used solutions or ointments for external use in hair loss patients, but these formulations lacked systematic research and conclusions on their efficacy and safety.


In 1987, the U.S. FDA approved 2% minoxidil solution in the United States, the product name Rogaine, used to treat male hair loss;

In 1996, the U.S. Food and Drug Administration (FDA) approved the production of minoxidil for the treatment of baldness and and rogen-based hair loss, and then European countries such as France and the United Kingdom began to sell, since 1986, the average monthly 2 percent minoxidil solution in Canada, it has a good reputation for safety. The incidence of side effects was less than 2% among approximately 24,500 users and no serious side effects occurred, and in recent years 5% and 2% of minoxidil have been used in clinical settings.

Minoxidil Powder

Minoxidil powder is a potassium channel activator that blocks the internal flow of calcium. Because of the presence of calcium, epidermal growth factor inhibits hair growth, so minoxidil can reduce epidermal growth factor-induced growth inhibition, so that hair growth accelerates. Dilatail blood vessels and reduce peripheral resistance.


Because it has a powerful effect on small blood vesseld dilation, improve the skin local microcirculation, increase the amount of blood supply of the skin, extend the survival time of epithelial cells, so that the lymphocytes around the hair follicles soaked away, promote hair growth, so that hair into final hair. When normal blood pressure and untreated hypertension patients were used locally, there was no indication of systemic effects caused by Minogue absorption.


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