Silybin (silibinin) is the highest content of water mothin, with the removal of free radicals, anti-lipid peroxidation, protection of liver cell membranes, promote the synthesis of DNA and structural proteins of damaged liver cells and antifiscosis and other pharmacological activities, for acute and chronic hepatitis, metabolic toxic liver injury and cirrhosis have a better effect, holy thistle extract has been marketed as a drug, It is recognized as a liver injury repair drug in the world.

Silymarin is a class of dihydroflavonoid compounds, has the effect of fighting liver poisoning, protecting liver cells and so on, can be used as bile excretion agent. Good efficacy is good for acute, diffuse hepatitis, cirrhosis, metabolic toxic liver damage, recurrent pain caused by gallstones and gallstones, and liver and gallalitis.

Major applications

Widely used in medical and health care, functional food and so on.

Efficacy and Function

Liver preservation antioxidant effect 

Silymarin can reduce liver cell damage caused by anti-lipid peroxidation, which maintains the fluidity of the cell membrane, thus protecting the liver cell membrane, and also inhibits the release of ultra-oxygen anions of neutrophils. Studies have also shown that holy thistle extract can increase the expression of superoxide dismutase (soD) in lymphocytes in mice with chronic alcoholic liver disease, which acts as an antioxidant effect. In addition, studies have reported that silybum marianum and silymarin can reduce the production of oxidizing substances such as reactive oxygen (reactive oxygen species, ROS) and propylene dialdehyde (malondialdehyde, MDA).

Anti-hepatic fibrosis       

Several studies have confirmed that Silymarin is antififiscandis by antioxidant and directly inhibiting the activation of various cytokines in hepatic astrocytes (HSC).

Liver protection and lipid-lowering effect   

Experiments in mice have shown that Silybin (silibinin) can reduce triglyceride (TG) levels and serum TG and total cholesterol (TCh) levels in the liver. And these animal experiments also showed that the liver pathology (such as fat change, inflammation and hepatocellular balloon-like change) improved to varying degrees after the intervention of silymarin silybin. There have also been studies suggesting that the drug can reduce the weight of the subjects.

Anti-inflammatory effects        

Silybin milk thistle powder can reduce the level syme of a variety of pre-inflammatory cytokines, such as IL-8, IL-6, MCP-1, and TNF-alpha, thus playing an anti-inflammatory role. This effect is achieved by inhibiting IKK-beta and p50, p65 activity, thereby inhibiting the action of NF-B.

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