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Resveratrol (trans-3,5,4′-trihydroxystilbene) and piceid (polydatin, resveratrol-3-O-β-mono- D-glucoside, the glycoside form of resveratrol) are the main active ingredients of Polygonum cuspidatum, which is a traditional Chinese medicine. This medicine has been used for thousands of years in the treatment of neuropsychiatric disorders.
Study indicate that resveratrol has chemoprevention effects against cardiovascular diseases, aging, and cancer. However, the absorption and metabolism of resveratrol have been extensively investigated by different research approaches. The oral bioavailability of resveratrol is extremely low due to rapid and extensive metabolism and the consequent formation of various metabolites such as resveratrol-glucuronides and resveratrol-sulfates. Thus, Experiments have yielded either positive or negative results. Some researchers conclude that resveratrol has no effects whereas others find it has a mild response.
Piceid is a precursor of resveratrol. The average content of piceid was found ten times higher than that of resveratrol in the Polygonum cuspidatum and red wine. What is more, piceid was the most abundant form of resveratrol in nature. A number of studies have suggested that piceid, like resveratrol, may have the similar bioactivities such as anticarcinogenic effects, inhibition of platelet aggregation, and antioxidation activity. Recently, it is found that both piceid and resveratrol have antiinflammatory activity that can decrease IL-17 production in a concentration-dependent manner in vitro. Up to now, it is still unclear whether piceid, like resveratrol, has the similar antioxidation and antitumor activities or possesses potential therapeutic advantage in clinic.
Xi'an Natural Field Bio-Technique Co.,Ltd. as Polygonum cuspidatum extract manufacturer, which is the professional Manufacturer of Herbal Extract Since 2005. They focus on researching and producing the Polygonum cuspidatum extract. The resveratrol 50% and 98%; Piceid 98% are the main products and specifications. If you need these products, please contact us or send an inquiry to [email protected] at any time.