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Apigenin is a kind of flavonoid compound, it is usually extracted from chamomile .Like other flavonoid compounds, chamomile extract apigenin podwer has the functions of anti-oxidation, anti-cancer, antibacterial, prevention and treatment of cardiovascular and cerebrovascular diseases.Among them, anticancer action is one of its important functions.
Chamomile extract apigenin podwer anti-tumor mechanism can be summarized as: Regulating cell cycle and apoptosis;Inhibition of hormone-related cancer;Inhibition of invasion;Metastasis and angiogenesis;Adjust multiple signaling pathways.
1. Breast cancer: Breast cancer is one of the common malignant tumors that harm women in China. Chamomile extract apigenin podwer mainly inhibits the growth of human breast cancer cells and promotes cell apoptosis.
2. Cervical cancer: Cervical cancer is one of the most common malignant tumors in human body, and it is the most common malignant tumor in women.Chamomile extract apigenin podwer can block human cervical cancer HeLa cells in G1 phase and induce its apoptosis and inhibit the growth of cancer cells.In addition, the expression of anti-apoptotic factor Bcl-2 protein is reduced, which leads to cell cycle arrest and apoptosis.
2. Ovarian cancer: Ovarian cancer is one of the common tumors in female reproductive organs, and lactin can activate transcription factor 3(ATF3) to inhibit the expression of Id1, thus inhibiting the proliferation of ovarian cancer A2780 cells.
4. Prostate cancer: Prostate cancer is an epithelial malignant tumor in the prostate gland, mostly in men over 50 years old, and one of the malignant tumors affecting the health of men.Chamomile extract apigenin podwer can inhibit the growth of prostate cancer cell line.
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