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NMN vs NR vs NAD+: The Differences Between These 2 NAD+ Precursors and NAD+
Feb 05, 2021

NMN is one of today’s popular health products. In this article, we will compare nmn with similar products nicotinamide ribose (NR), oxidized nicotinamide adenine dinucleotide (NAD+)and so on are briefly distinguished. nmn powderNicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are biosynthetic precursors to an essential molecule for metabolism— nicotinamide adenine dinucleotide (NAD+). These ingredients are all oral products as dietary supplements. NMN and other NAD+ precursors such as nicotinamide ribose (NR), niacin (NA) and nicotinamide (NAM) all contain a pyridine ring structure;


Nicotinamide ribose (NR) is the precursor substance of nmn, naturally present in milk and dairy products. In 1944, NR was first discovered by scientists as a growth factor of Haemophilus influenzae. In 2004, NR was used as a precursor of NAD+ for anti-aging research. In 2012, NR began to be industrialized as a dietary supplement to raise the level of NAD+. NR in its natural form is extremely unstable, and NR currently used in dietary supplements is in its chloride form. nmn nr nadThe biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. In the NAD+ precursor, nicotinamide ribose (NR) and NMN There are exceptions. The adverse side effects of these two metabolites are rarely reported. NR and NMN have the same oral bioavailability.

Oxidized nicotinamide adenine dinucleotide (NAD+) or nicotinamide adenine dinucleotide, or oxidized coenzyme I. NAD+ is widely present in various foods, and the metabolism of all living cells is inseparable from Coenzyme I. NAD+ was first discovered in the alcohol fermentation process of yeast in 1904. With the rise and deepening of NAD+ anti-aging research, around 2018, dietary supplements with NAD+ as the main ingredient appeared on the market. However, studies on the bioavailability of NAD+ have shown that ingested NAD+ is mainly hydrolyzed by brush border cells in the small intestine.

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