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Luteolin interferes with nearly all types of cancer cells. Luteolin powder 98% inhibits the growth of new blood vessels in tumors, the metabolism of carcinogens, as well as stopping the progression of the cell cycle in cancer cells. Pure Luteolin powder also induces cell death in cancer cells. In mice, luteolin suppressed growth of tumors formed from human skin carcinoma, hepatoma, and human ovarian cancer cells. Luteolin supplements inhibited the incidence rate of tumors and decreased the size of tumors significantly.
Experiments with animals show that luteolin suppresses bacteria-induced inflammation. Luteolin supplement is also found to suppress two major pathways involved in response to inflammation, which greatly reduces both acute and chronic inflammation. Luteolin suppressed pro-inflammatory marker expression and cytokine expression in LPS-activated microglia. In an experiment on rats with toxin-induced uveitis, luteolin had great success in anti-inflammatory treatment, comparable to that of prednisolone. Luteolin can also inhibit colitis (inflammation in the colon).
Luteolin is an oxygen scavenger. It was found to inhibit reactive oxygen species, which induce damage of lipids, DNA, and protein. Luteolin significantly induces genes related to antioxidant defense.
Luteolin potently inhibited UVB-induced MMP-1 expression and wrinkle formation in vitro and in vivo and therefore may be used for prevention of UVB-induced skin aging.
In an experiment on rats, luteolin was found to inhibit cell death in the cells of the heart. This suggest that luteolin can be used in the prevention and treatment of cardiovascular diseases. Luteolin substantially increased cell life while reducing evidence of oxidative stress-induced damage in the cells. Luteolin also improved the recovery of heart cells contracting function following simulated injury caused by loss of blood flow, by reducing oxidative stress.
Luteolin treatment in rats reduced brain damage caused by kainic acid by reducing glutamate levels, mitigating inflammation, and enhancing the hippocampus. Tests on flies expressing a neurological impairment that resembles amyloidosis showed that luteolin rescued the impairment. Luteolin induces neurite outgrowth through CREB activation. CREB activation is the mechanism underlying its effects on memory enhancement. Luteolin can go through the blood-brain-barrier (BBB), which shows anti-amnesic effects against the toxicity of amyloid in mice. In an experiment on rats with streptozotocin induced Alzheimer’s disease, luteolin significantly improved spatial learning and memory impairment. Luteolin also protects against high-fat diet-induced cognitive defects in obesity mice.
Luteolin was found to have potent antiviral activity against Japanese encephalitis virus (JEV). Luteolin reduced the number of Epstein-Barr virus reactivating cells and reduced the production of the virus. It does this by repressing the activities of the promoters of the immediate-early genes Zta and Rta. In mice with hepatitis B virus (HBV), Luteolin reduced HBV DNA replication, suggesting that it may be used for anti-HBV therapy.
In rats, luteolin enhanced the antioxidant potential and lowered the oxidative damage to the lens’ of rats in selenite-induced cataracts. It also improved the membrane integrity of the lens.
Multiple Sclerosis is a disease that affects the immune system – nerve damage causes pain and fatigue. Luteolin has anti-oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis.
Luteolin inhibits mast cells and mast cell-dependent T cell activation, factors which contribute to multiple sclerosis. In this way, it can also help with histamine intolerance.
The endoplasmic reticulum in a cell can undergo stress, which can cause cell death. In the brain, neuronal cells undergo cell death and this can cause symptoms of depression. Luteolin significantly suppresses cell death by relieving endoplasmic reticulum stress.
Luteolin can stop the effects of progesterone while increasing the effects of estrogen at the same time.
While luteolin can help stop spontaneous colitis, it can also increase the effects of dextran sodium sulfate (DSS)-induced colitis. It blocks protective molecules in intestinal cells which prevent inflammation in the colons due to DSS.
Xi'an Natural Field Bio-Technique Co.,Ltd. as luteolin Manufacturer, which is the professional Manufacturer of Herbal Extract and chemical products Since 2005. They focus on researching and producing the related pharm and cosmetics raw material. such as the luteolin hplc. Our high purity active ingredients is tested by HPLC. therefore, luteolin 98% in bulk can be approved. If you need these products, please contact us or send an inquiry to [email protected] at any time.