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The flavonoid isoquercitrin HPLC 98% (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (α-glucosylated) isoquercitrin" (EMIQ).
Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with α-L-rhamnosidase. The Isoquercitrin benefits decide the Isoquercitrin usage. the isoquercitrin uses are as following:
Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, Isoquercitrin cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver. Biotransformation of isoquercitrin includes deglycosylation, followed by formation of conjugated and methylated derivatives of quercetin or degradation to phenolic acids and carbon dioxide.
The acceptable isoquercitrin dosage of daily intake of (95%) isoquercitrin and of EMIQ was estimated to be 5.4 and 4.9mg/kg/day, respectively. Adverse effects of higher doses in rats included mostly (benign) chromaturia; nevertheless some drug interactions may occur due to the modulation of the activity and/or expression of drug metabolizing/transporting systems. With respect to the safety, affordability and beneficial pharmacological activities, highly pure isoquercitrin is a prospective substance for food supplementation.
Toxic effects on larvae of cotton-fly bud Worms in the agricultural field.
Xi'an Natural Field Bio-Technique Co.,Ltd. as Isoquercitrin Manufacturer, which is the professional Manufacturer of High purity ingredients and chemical products Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. Isoquercitrin uses is widely used for pharma and cosmetics field. If you need this product and related product, please contact us or send an inquiry to [email protected] at any time, we will quote our best Isoquercitrin price.
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