Email: [email protected]
5th Floor, Building B, No.57,Keji 3rd Road,High-Tech Zone, Xi'an,710075,China
No 6, Caotang Industry Park, No.2 Qinling Road, Hi-tech Zone, Xi'an, China
Product Name: Indole-3-Carbinol
Chemical name: Indolemethanol; Indole-3-carbinol; 3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol; Indole-3-methanol; 1H-Indole-3-methanol
Cas No: 700-06-1
Einecs No: 211-836-2
Molecular formula: C9H9NO
Molecular weight: 147.18
Indole 3 carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage,cauliflower, brussels sprouts, collard greens and kale. indole-3-carbinol is also available in a dietary supplement. indole-3-carbinol is the subject of on-going Biomedical research into its possible anticarcinogenic, antioxidant, and antiatherogenic effects.
Indole-3-carbinol can shift estrogen metabolism towards less estrogenic metabolites. indole-3-carbinol has an effect on human papilloma virus infected cells in both pediatrics and adult patients.
Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.
Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.
The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.
A few studies demonstrate the beneficial effects of indole-3-carbinol on lipid synthesis and platelet aggregation, suggesting that this phytochemical could help to improve heart health.
Xi'an Natural Field Bio-Technique Co.,Ltd. is the professional Manufacturer of Herbal Extract and chemical products Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. Indole-3-carbinol and anti-cancer raw material series are the main and strong products. If you need related products, please visit their website www.nfnutra.com or send an inquiry to [email protected] at any time.