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Hyaluronic Acid Benefits
Dec 11, 2021

Hyaluronic Acid's excellent biocompatibility, water absorption, viscoelasticity, non-antigenicity, and degradable non-toxicity make it suitable for use in ophthalmology, surgery, rheumatology, urology, and other fields, as well as for the treatment of inflammation, Improve multi-drug resistance, assist in angiogenesis, prevent tumors and change the viscoelasticity of extracellular matrix.

1 Ophthalmology

High-concentration HA has the characteristics of good viscoelasticity, weak fluidity, and molecular barrier. Using this feature, HA can be used for anterior and posterior ophthalmic surgery, including intracapsular/extracapsular cataract surgery, intraocular lens implantation surgery, and corneal transplant surgery, Glaucoma filtering surgery and retinal reattachment surgery, etc., can also be used as a substitute for filling vitreous in the two operations of vitrectomy and retinal detachment. At the same time, HA is also the main component of eye drops (treatment of dry eye), which can effectively prolong the tear film rupture time, reduce the number of blinks in patients with dry eye, and relieve the symptoms of dryness, astringency, itching, and pain.

2 Surgery

HA is often used in surgery to prevent or reduce postoperative adhesions after abdominal (pelvic) surgery. The anti-adhesion function is due to the spatial blocking effect of HA. Its mechanism of action is mainly: ① Separate tissues through physical shielding, and shield inflammatory mediators and bacteria; ② Promote fibrinolysis, and at the same time stimulate the expression of CD44 receptors, Promote the proliferation of mesothelial cells; ③regulate collagen synthesis, enhance macrophage activity, reduce fibrin deposition, promote wound healing and reduce scar formation; ④form a protective film on the tissue surface to reduce mechanical damage, and to lubricate and smooth the surface Moisturizing; ⑤ absorption of swelling and compression of bleeding points, can play a role in inhibiting bleeding.

3 joints

HA exists in joint synovial fluid in the form of sodium salt and is one of the components of the cartilage matrix. It can lubricate the joint cavity, reduce the friction of the connective tissue, and cushion the compression of the articular cartilage from external forces. Injecting exogenous high molecular weight, high concentration, high viscoelastic HA into the joints can restore the synovial fluid to a normal state and promote the natural repair of cartilage.

4 Plastic surgery

HA has good biocompatibility, hydrophilicity, and reversibility (injected HA can be decomposed by hyaluronidase), but natural HA has poor stability, is prone to degradation, and is too hydrophilic. Modification and modification to develop HA with better biological activity and functionality. The modified HA can be used as a tissue filler to replace the lack of dermal tissue volume due to aging.

5 Wound repair

HA can be used for pain treatment after tonsillectomy. In addition, HA can be used to relieve pain, wound repair, arthritis, tendon disease, surgical treatment of deep wounds, burns, local deep burns, surgical wounds of epithelial tissues, and chronic wounds.

6 In tissue engineering and regenerative medicine, HA-based biomaterials or biological scaffolds are used in tissue engineering to enhance the efficacy of regenerative medicine. Regenerative medicine mainly refers to diseases of vital organs, control of drug release, growth factors, and antibodies, facial or intradermal implants. HA has become the most suitable biopolymer in tissue regenerative medicine.

 

As one of the main components of the extracellular matrix, hyaluronic acid is widely used in ophthalmology, surgery, arthritis, plastic surgery, and other fields due to its good biocompatibility, hydrophilicity, antigenicity, and lubricity. The field of tissue engineering has shown good application potential. Among them, hyaluronic acid is relatively mature in the fields of ophthalmology, surgery, arthritis, and wound repair, but its application in the fields of plastic surgery and tissue engineering needs to guide the design and improvement of hyaluronic acid products according to the specific needs of each indication, Improve its performance and biocompatibility.

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