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IUPAC name: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
CAS Number: 58186-27-9
PubChem CID: 3686
Molar mass: 338.439 g/mol
Idebenone is a synthetic analogue of coenzyme Q10. Coenzyme Q10 (ubiquinone) –vitamin-like compound that is produced in the liver subject to receipt in the required amount of vitamins B2, B3, B6, C, folic and pantothenic acid. In case of a shortage of any of these vitamin’s synthesis of coenzyme Q10 suppressed. Ubiquinone stimulates the production of the primary energy molecules – adenosine triphosphate (ATP). With age, the content of coenzyme in the body falls, and is useful for slowing the aging process and prevents degenerative diseases. The use of natural coenzyme Q10 has several limitations. Ubiquinone molecule is quite big (about 50 carbon residues in the side chains), and having a high hydrophobicity impedes its passage through the membrane. In addition, under certain conditions instead of the antioxidant effect may occur pro oxidant properties soedineniya.S in order to overcome these shortcomings, attempts to synthesize derivatives of coenzyme Q10, retains all its positive properties of natural counterpart, but devoid of its drawbacks. To date, only one of the plurality of synthesized molecules in this series has been approved as a drug. Idebenone inhibits lipid peroxidation by protecting neuronal membranes and mitochondria from damage. Coenzyme Q10 is a component of the electron transport chain, located in the inner mitochondrial membrane. It accepts electrons from complexes, I (NADH-ubiquinone reductase-oksidore) and II (succinate dehydrogenase) for onward transmission to complex III (ubiquinone reductase tsitohroms). Oxidative phosphorylation, is realized by the production of ATP, is an important process used in the production of energy to maintain the functions of organs such as the brain, heart, myshtsy.Naryadu with metabolic and trophic effect of idebenone has both nootropic properties. Increasing the metabolous processes in the brain by activating the synthesis of glucose, ATP, improves blood circulation and nutrition of tissues, it also contributes to elimination (removal) of lactate.
According to clinical practice, idebenone improves the speed of sensorimotor reactions, has a marked effect on specific cognitive processes, improving performance and short-term memory and attention. Additionally, the compound possesses a strong antioxidant effect. Thus, the indications for the drug are: tse-rebrovaskulyarnye disorders, asthenic conditions, psycho-organic syndrome, emotionally labile disorder. From the first days of idebenone shows antiastenicheskoe, psychostimulant and antidepressant effects; nootropic effect manifests in 3-4 weeks. General cytoprotective efficacy of the drug determines its use in gerontology.
Xi'an Natural Field Bio-Technique Co.,Ltd. as Idebenone Manufacturer, which is the professional Manufacturer of Herbal Extract and chemical products Since 2005. They focus on researching and producing the related pharm and cosmetics raw material. such as the idebenone and coenzyme q10. Our high purity active ingredients is tested by HPLC. therefore, idebenone hplc 98% can be approved. If you need these products, please contact us or send an inquiry to [email protected] at any time.