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Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen. It was first isolated in 1899 from the dyer's broom, Genista tinctoria; hence, the chemical name. The compound structure was established in 1926, when it was found to be identical with that of prunetol. It was chemically synthesized in 1928.
Genistein extract powder is the most effective isoflavone extracted from soybeans. It has exhibited diverse biological activities shown realiable genestein benefits in cancer prevention and genistein cancer treatment. Through regulating critical cell cycle genes, genistein can inhibit cancer cell growth in vivo and in vitro. It has been reported that genistein can inhibit activation of NF-κB and Akt signaling pathways to induce cell apopt1osis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. In order to find out more outstanding anticancer isoflavone agents, against cancers extended synthesis of genistein derivatives has been carried out. Some of these synthetic compounds demonstrated higher anticancer activity with lower doses. Based on these results, genistein and genistein synthetic derivatives may be an emerging new type of anticancer agents.
During last decade, many researchers have conducted extensive studies by synthesizing amounts of structurally-modified derivatives based on the isoflavone skeleton of genistein to enhance its anticancer activity, some analogs of which possess more potent activities of the prevention and/or treatment of various cancers. In this review, we summarized the current knowledge regarding anticancer effects,structure-activity relationships and action mechanisms of genistein and its synthesized analogs, which would be beneficial to the rational design of new genistein derivatives as anticancer drugs.
Previous epidemiological and experimental studies have suggested that genistein may play promising roles as a chemopreventive or therapeutic agent against ovarian cancer. In addition to its hormonal action, the anticancer effects of genistein are related to multiple cellular signaling pathways such as PTK, Akt, NF-κB, MMP, and Bax/Bcl-2. Because the successful treatment of ovarian cancer is limited mainly by the development of chemotherapy resistance, genistein is expected to play a role in sensitizing multiresistant ovarian cancer cells and have additive effects with conventional chemotherapeutic agents. Although some clinical trials are now being performed to identify the role of genistein as an anticancer agent against various types of cancers, there is currently no registered clinical trial on ovarian cancer. Further research should be performed to identify the role of genistein in ovarian carcinogenesis.
Xi'an Natural Field Bio-Technique Co.,Ltd. as genistein manufacturer, which is the professional Manufacturer of Herbal Extract Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. genistein is the one of strong products for anti-cancer, we will supply our best genistein price and service to you. genistein 98% natural and synthetic genistein 98% can be provided to you. Also, we can supply the genistein powder for customers. If you need this product and related product, please contact us or send an inquiry to [email protected] at any time.