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Application of Indole-3- Carbinol
Nov 20, 2017

Indole-3- Carbinol and cancer


I3C (indole 3 carbinol acne, indole 3 carbinol and breast cancer) can effectively prevent estrogen-related cancers such as indole 3 carbinol breast cancer prevention, endometrial cancer and cervical cancer , and is expected to become a breast cancer chemical anti-cancer agents and therapeutic agents. I3C has multiple anti-cancer and anti-tumor activity. The possible mechanisms for the prevention of breast cancer include: regulating G1 / S cell cycle arrest and inducing apoptosis, anti-estrogen activity, inhibiting the formation of DNA adducts and inducing DNA repair.

I3C have been found to modulate the expression and activity of biotransformation enzymes that are involved in the metabolism and elimination of many biologically active compounds, including steroid hormones, drugs, carcinogens, and toxins.


Indole-3- Carbinol and dietary supplement


I3C (indole 3 carbinol and weight loss) is available without a prescription as a dietary supplement, alone or in combination products.

 

Indole-3- Carbinol and Melanoma


Indole 3 carbinol cancer causes proliferation arrest and apoptosis in human melanoma cells. Kim YS et al showed that the master regulator of melanoma biology, Micropthalmia-associated transcription factor (MITF-M) was downregulated by Indole-3-carinol to induce apoptosis. Kundu A et al demonstrated that the anticancer property of Indole-3-carbinol is driven by specific targeting of oncogenic pathways. In two different studies using xenografted mouse model of melanoma, they observed that subcutaneous injection of Indole-3-carbinol could bring down tumor burden significantly. The underlying molecular mechanism of this anti-tumor effect was found to be by the specific inhibition of activity of oncogenic BRAFV600E in tumors that harbored the mutation. However in tumors that expressed wild type BRAF, Indole 3 carbinol cancer treatment did not cause any comparable antiproliferative effect. Additionally Indole-3-carbinol did not cause antiproliferation even in normal epidermal melanocytes underscoring the specificity and selectivity of its action. Kundu et al further showed that inhibition of BRAF V600E activity by Indole-3-carbinol resulted in downregulation of MITF-M by downstream signaling which caused a G1 cell cycle arrest leading to the observed antiproliferative effect.

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Indole-3- Carbinol and Systemic lupus erythematosus


Indole-3-carbinol dosage bodybuildingl can shift estrogen metabolism towards less estrogenic metabolites. Systemic lupus erythematosus (SLE, or lupus), an autoimmune disease, is associated with estrogen. In a study using mice bred to develop lupus, indole-3-carbinol was fed to one group while another group was fed a standard mouse diet; the group fed the indole-3-carbinol diet lived longer and had fewer signs of disease.

Another study of lupus prone mice with indole-3-carbinol defined the mechanism for the improvement of their disease to be due to sequential blocks in the development of B and T cells of these mice. The maturation arrests resulted in a fall in autoantibody production, thought to be a crucial component of lupus causation. In addition, I3C supplementation of the disease prone mice led to a normalization of their T cell function.

Women with lupus can manifest a metabolic response to indole-3-carbinol and might also benefit from its antiestrogenic effects. Clinical trials are currently underway to determine the efficacy of treating human patients suffering from lupus with indole-3-carbinol.

 

Dosage for Indole-3- Carbinol


Indole 3 carbinol dosage is available as a dietary supplement, alone or in combination products. Dosage ranges between 200 mg/day and 800 mg/day .

I3C supplementation increased urinary 2HE1 concentrations in adults at doses of 300 to 400 mg/day . I3C doses of 200 mg/day or 400 mg/day improved the regression of cervical intraepithelial neoplasia (CIN) in a preliminary clinical trial. I3C in doses up to 400 mg/day has been used to treat recurrent respiratory papillomatosis.


Where Can You Buy Indole-3-Carbinol?


Xi'an Natural Field Bio-Technique Co.,Ltd. is the professional Manufacturer of Herbal Extract and chemical products Since 2005. And attend the CPHI, Vitafoods and API Exhibition from 2008. Indole-3-carbinol and anti-cancer raw material series are the main and strong products. If you need this product and related product, please contact us or send an inquiry to info@natural-field.com at any time.