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It was proposed in 1999 that atherosclerosis is an inflammation disease, characterized by a pathological process of chronic inflammatory response. Experiments have shown that phycocyanin in spirulina improve the level of antioxidant enzymes in the body by inhibiting the production of active free radicals and epoxyase-2, effectively improving the inflammatory damage caused by oxidative stress in atherosclerosis animals, and has the effect of regulating blood lipids.
Because the formation of atherosclerosis lesions is the result of inflammation-fibre hyperplasia reaction of arteries to endometrial damage, the inhibition and mechanism of blunt-top spirulina phycocyanin on blood vessel smooth muscle cells, endometrium proliferation and tube cavity stenosis after vascular injury were studied through in vivo and external experiments.
It is proved that phycocyanin can inhibit the process of cell G1/S cycle, inhibit the excessive proliferation of VSMCs and the formation of the new endometrium, thereby reducing the damage of vascular oxidation inflammation, and significantly inhibit the stenosis of the tube cavity, so it is proved that the antioxidant activity of phycocyanin has a good preventive effect on vascular health. The activation of c-phycocyanin on hemoglobin oxygenase-1, an enzyme that allows hemoglobin to break down and metabolize to produce powerful antioxidant bilirubin.
Experimental results show that phycocyanobilin in spirulina reduces oxidative stress, activates HMOX1 in the epithelial cells, and causes the expression of HMOX1 to be increased in atherosclerosis lesions in mice with a lipoprotein E gene defect. This also provides a new theoretical basis for c-phycocyanin to reduce atherosclerosis, i.e. to increase the expression of hemoglobin oxygenase-1 to increase antioxidant effect.
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