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Aloe emodin ( AE) , a natural biologically active ingredient of anthraquinone, is mainly derived from Aloe, Rhubarb, Cassia. In recent years, Aloe-emodin has attracted much attention due to its various effects such as cardiovascular protection, hepatoprotective activities, anti-tumor, antibacterial, antifungal, antiviral, anti -inflammatory, skin conditioning, immune regulation, laxative.
The pathogenesis of cardiovascular disease is complex and has the characteristics of multiple factors affecting each other, among which endothelial cell dysfunction caused by excessive oxygen free radicals is closely related to hypertension, hyperlipidemia and early atherosclerosis, coronary heart disease, congestive heart failure, arrhythmia and myocardial ischemia. To study the removal effect of aloe emodin uses on super-oxygen anion free radical (O2-), the results show that aloe-emodin has an IC50 of 6.8 mg on super-oxygen anion free radicals. L-1, and aloe emodin powder had a significant dose dependence on the removal capacity of oxygen free radicals. The results suggest that the role of Aloe-emodin 95 removal of oxygen free radicals may play an important role in the treatment of cardiovascular disease.
The results showed that aloe-emodin was found to have a blood pressure reduction effect on the main components of aloe vera at 0. 5,1,3 mg.kg - 1 dose,
the dose dependence lowers the average arterial blood pressure; At a dose of 3 mg - 1, arterial blood pressure decreased by 79%, but its blood pressure reduction mechanism was not clear and needed further study.
Hyperlipidemia is caused by a disorder of lipid metabolism in the body, The pathological physiological state, which manifests as an increase in blood lipid level, can lead to the formation of atherosclerosis and is the main factor of many cardiovascular diseases.
Hyperlipidemia not only causes increased blood viscosity and hemodynamic abnormalities, but also can cause the increase of super-oxygen anion free radicals, chain causes the body's antioxidant capacity to decrease, lipid peroxide increase, resulting in significant lipid peroxidation damage (such as vascular endothelial dysfunction).
Aloe-emodin removes the effect of oxygen free radicals, making it possible to have the effect of lipid adjustment. It has also been reported that aloe emodin powder inhibits fat cell differentiation and maturation by reducing mRNA expression levels such as lipophilin, lipoprotein lipothane, and the occurrence of lipophilin, lipoprotein lipothane and high-lipid aherosclerosis.
The above findings suggest that aloe vera extract aloe emodin removes oxygen free radicals, lowers blood pressure, and potentially lipid-regulating effects, making it possible to use for the treatment of hypertension, hyperlipidemia and atherosclerosis, as well as further prevention and treatment of complications such as coronary heart disease induced by such conditions, thereby reducing the risk of other cardiovascular diseases. This gives effect to cardiovascular protection.
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