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Agricultural Raw Materials

5-ala Used In Agriculture Field

5-ala Used In Agriculture Field

Product Code: NF-026
Product name:5 Aminolevulinic Acid HCl
Specification: 98.0%-102.0%
Certifications: ISO, HACCP, CQC, KOSHER
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5-ala Used In Agriculture Field Oil Introduction

5-ALA (CAS: 5451-09-2) is suitable for a wide range of scientific fields, such as increasing harvest yield or increasing plant green. Supplementary studies from animal cultures of microorganisms or cells related to reactive oxygen species produced from the accumulation of excess porphyrins are used for photodynamic diagnosis of cancer research.

5451-09-2.jpg

5-ALA.jpg


Description

5-Aminolevulinic acid (ALA), an endogenous biochemical substance produced by ALA dehydratase and a series of enzymatic actions to produce protoporphyrin IX (PPIX) with strong photosensitivity. The synthesis speed of PPIX depends on the picking speed of this product, and this product is regulated by the feedback of free hemoglobin concentration. The exogenous product can bypass the feedback inhibition system and make the cells synthesize a sufficient amount of PPIX. Cancer tissue containing PPIX is irradiated with 420-640 nm light, and singlet oxygen (-O2) is generated during energy transfer. When the oxygen reaches a certain concentration, the cancer cells can be destroyed. Another kind of cleanliness is that after the light irradiation, the excited state PPIX directly interacts with biomolecules or transfers energy to oxygen and water to form free radicals, which cause a series of chain reactions of biomolecules through free radicals, causing cancer cells to die. Svanbery et al. found that the ratio of PPIX content in tumor tissue was 1:2.


Specification of 5-ALA used in Agriculture Field

Product  name:

5-ALA (CAS:5451-09-2)used in Agriculture Field

CAS No:

5451-09-2

Ref.standard

Enterprise standard

Batch  Number:

NF-20170925

Manuf.  Date:

Sep. 25, 2017

Batch Size:

86.4kg

Expiry  Date:

Sep. 24, 2019

Storage  Condition:

Preserve in tight, light  resistant containers at 2℃ - 8℃.

TEST ITEM

SPECIFICATION

RESULTS

Appearance

Almost white to off-white crystalline  powder

Almost white crystalline powder

Identification

HPLC

Conform

Loss on  drying

≤1.0%

0.32%

Melting  point

150℃--155℃

151.1℃--152.3℃

Residue  on ignition

≤0.5%

0.06%

Heavy  metals

≤20ppm

Conform

Iron

≤20ppm

Conform

Bacteria endotoxins

≤0.4 USP EU/mg

Conform

Microbial  Limits

Total aerobic microbial count

≤100 cfu/g

Conform

Staphylococcus aureus

Absence

Absence

Pseudomonas aeruginosa

Absence

Absence

Salmonella species

Absence

Absence

Escherichia Coli

Absence

Absence

Impurities

Any other single  impurity

≦0.3%

Conform

Total impurities

≦1.0%

0.30%

Assay

98.0%-102.0%

99.92%

Conclusion

The lot meets the specifications

5-ALA HCl chromatogram map.jpg


Main Functions

1. It can be used in help plant grow regular;

2. It can used to cure cancer

3. It can improve skin aging and remove the acne and spot.


Pharmacological action

Regular et al found that PP IX is three to four times higher than normal cells in gastric cancer cells. Experiments have shown that the conversion of ALA to endogenous PPIX in vivo has higher selectivity, and the conversion rate of tumor cells and some cells is faster, so the content of PPIX in cells is higher than other cells. This is the basis for ALA-light, Dynamic Therapy (ALA-PDT) treatment. When Svanber used the product to treat tumors, there was no significant change in tumor blood vessels before and after body surface treatment. This indirectly indicates that the method utilizes cytotoxicity to kill cells rather than destroying or blocking tumor blood vessels using cell necrosis. In another experiment, cells treated with the product were observed with an electron microscope. The results showed that after 1 h, the mitochondria were obviously swollen, the sputum disappeared, and other cell organs did not change significantly. However, after 24 hours, the entire cell was necrotic, indicating that the killer cells of the product may be the first, and mitochondrial damage leads to cell death.

When the product is treated, normal tissue surrounding it is not selectively destroyed, such as oxidized proteins, liposomes and other subcutaneous cell structures. Therefore, oxygen free radicals produced under pathological conditions in which the product is overloaded will result in acute circulating porphyria. In addition, this product causes the release of iron ions in ferritin, which exacerbates the oxidation of cells, leading to acute periodic porphyria. It has been reported that this product and GABA may enter cells through a common carrier protein and thus have a neurotoxic effect in the pathogenesis of acute porphyria. It has been shown that the oxygen free radicals induced by this product can oxidize DNA, which may lead to the deterioration of hepatocellular carcinoma in patients with acute periodic dementia. However, Mustajoki and other male healthy volunteers injected 50-80 mg / h for 92.5 h, and they had no symptoms, no changes in pulse, blood pressure, autonomic function and peripheral nerve conduction velocity, nor no photoallergies. It can be speculated that maintaining a high dose of this product in healthy volunteers does not cause symptoms similar to porphyria.


Application

1. In the pharmaceutical field, Levulan, mainly can be used as photosensitizer;

2. In the agriculture field, 5 ala hcl, can be used as a new environmently friendly plant growth regulator ;

3. In cosmetics field, 5-Aminolevulinic Acid Hydrochloride can be used as raw materials to improve skin aging and remove the acne and spot.

5 ala.jpg

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